World’s most advanced CT scanner to see through solids

Washington, September 11 (ANI): Researchers at The University of Nottingham, UK, have created the most advanced 3D X-ray micro Computed Tomography (CT) scanner in the world, which will help scientists from a wide variety of departments across the University literally see through solid materials, including soil.

Known as the ‘Nanotom’, the machine will make previously difficult and laborious research much easier as it allows researchers to probe inside objects without having to break into them.

The Nanotom will produce high-resolution 3D and slice images of solids with a pixel resolution of up to half micron or 500 nanometres.

It will be based at the School of Biosciences as the centrepiece of research into efforts to understand the microscopic interactions between plant root growth and soil structure.

The first project to use it will examine the sensing ability of roots to grow in the best direction for the health of the plant through the soil.

It aims to provide evidence of how the root reacts and adapts to soil stresses like drought and compaction by adjusting the genetic information in the tips of the root as it grows.

The Nanotom will allow researchers to follow the progress of the root growth and soil structural development for the first time without disturbing the sample of the plant growing in the soil.

The eventual aim of research like this is to contribute to worldwide efforts for food security and sustainable food production by preserving and improving the vital but finite soil resources of the planet.

It will enable scientists to come up with a recipe for the best soil composition and level of compaction as well as informing plant breeding programmes.

Accurate soil structure measurement will be also be essential in changing farming practices to cut CO2 which is released into the atmosphere during traditional ploughing of agricultural soil.

According to Dr Sacha Mooney from the University’s Division of Agricultural and Environmental Sciences, “This new kit will completely revolutionize our work in trying to understand the key factors that control some of the many functions that soils perform.”

“Of course it’s not just soils we’ll be scanning, I think I am just as excited about the opportunity to look inside newly created environmental building materials, eco-friendly crops developed to improve yield and even chocolate bars for the food industry,” Mooney added. (ANI)

Coming soon: 15-minute, $100 human genome sequencing

Washington, July 28 (ANI): Human genome sequencing is expected to become as cheap as 100 dollars per case, and that too at speeds 20,000 times faster than second-generation sequencers currently on the market, with a new device being developed to watch DNA being copied in real time.

Stephen Turner, the Chief Technology Officer at Pacific Biosciences, has revealed Single Molecule Real-Time (SMRT) sequencing will be released commercially in 2010.

A decade ago, it took Celera Genomics and the Human Genome Project years to sequence complete human genomes.

In 2008, James Watson’s entire genetic code was read by a new generation of technology in months.

With SMRT sequencing, Pacific Biosciences experts expect to accomplish the same feat in minutes.

The method used in the Human Genome Project taps into the cell’s natural machinery for replicating DNA.

The enzyme DNA polymerase is used to copy strands of DNA, creating billions of fragments of varying length. Each fragment ends with a tiny fluorescent molecule that identifies only the last nucleotide in the chain, and by lining these fragments up according to length, their glowing tips can be read off like letters on a page.

Instead of inspecting DNA copies after polymerase has done its work, SMRT sequencing watches the enzyme in real time as it races along and copies an individual strand stuck to the bottom of a tiny well.

Every nucleotide used to make the copy is attached to its own fluorescent molecule that lights up when the nucleotide is incorporated, and this light is spotted by a detector that identifies the colour and the nucleotide – A, C, G, or T.

The researchers behind this technology hope that repeating this process simultaneously in many wells may help bring about a substantial boost in sequencing speed.

“When we reach a million separate molecules that we’re able to sequence at once … we’ll be able to sequence the entire human genome in less than 15 minutes,” said Turner.

The device also has the potential to reduce the number of errors made in DNA sequencing. Given that the errors made by SMRT sequencing are random, that is not systematically occurring at the same spot, they are more likely to disappear as the procedure is repeated.

A presentation on “Single Molecule Real-Time DNA Sequencers” was made at the 2009 Industrial Physics Forum, a component of the 51st Annual Meeting of American Association of Physicists in Medicine, on Monday. (ANI)

Orangutans can counter dangerous tree vibrations by moving in an irregular rhythm

Washington, July 28 (ANI): A team of scientists has found that the orangutan can counter dangerous tree vibrations by its ability to move with an irregular rhythm.

According to Professor Robin Crompton, from the University of Liverpool’s School of Biomedical Sciences, there is a problem in the movement of animals through the canopy of tropical forests, where there are highly flexible branches.

“Most animals, such as the chimpanzee, respond to these challenges by flexing their limbs to bring their body closer to the branch. Orangutans, however, are the largest arboreal mammal and so they are likely to face more severe difficulties due to weight,” he said.

“If they move in a regular fashion, like their smaller relatives, we get a ‘wobbly bridge’ situation, whereby the movement of the branches increases,” he added.

“Orangutans have developed a unique way of coping with these problems; they move in an irregular way which includes upright walking, four-limbed suspension from branches and tree-swaying, whereby they move branches backwards and forwards, with increasing magnitude, until they are able to cross large gaps between trees,” according to Dr Susannah Thorpe, from the University of Birmingham’s School of Biosciences.

The team studied orangutans in Sumatra, where the animal is predicted to be the first great ape to become extinct.

This new research could further shed light into the way orangutans use their habitat, which could support new conservation programmes.

“If the destruction of forest land does not slow down, the Sumatran orangutan could be extinct within the next decade,” Dr Thorpe said.

“Now that we know more about how they move through the trees and the unique way that they adapt to challenges in their environment we can better understand their needs.

This could help with reintroducing rescued animals to the forests and efforts to conserve their environment,” she added. (ANI)

Reducing gasoline emissions will benefit human health

Washington, May 29 (ANI): A new study has shown that shown that a biofuel eliminating even 10-percent of current gasoline pollutant emissions would have a beneficial impact on human health.

While the focus of a shift from gasoline to biofuels has been on global warming, such a shift could also impact human health.

A grant from the Energy Biosciences Institute (EBI) has produced a novel and comprehensive “Life Cycle Impact Assessment” (LCIA) to measure the benefits on human health that might result from a switch to biofuels.

Although there are a number of uncertainties that must be addressed for a more accurate picture, these early results show that a biofuel eliminating even 10-percent of current gasoline pollutant emissions would have a substantial impact on human health, especially in urban areas.

Assessments of the life cycle impacts of emissions from gasoline-run motors in the US on a county-by-county basis show that the heaviest damage (darkest coloring) is concentrated in urban areas, especially Los Angeles, New York and Chicago.

Nonetheless, Thomas McKone, an expert on health risk assessments and EBI researcher Agnes Lobscheid, were able to prepare an LCIA for reduced gasoline use based on the damage to human health that emissions from gasoline burning can cause.

For a baseline, they used a 10-percent reduction in gasoline use.

In assessing the impact of these emissions on human health, they looked at “disability adjusted life years” or “DALYs,” which is a combination of two common damage factors in LCIAs – years of life lost due to premature mortality (YLLs) and the equivalent years of life lost due to disability (YLDs).

“In looking at emission impacts on health, we have the capacity to carry out county-level resolution measurements for both direct and indirect emissions,” said McKone.

Measured emissions at county-level resolution included direct particulate matter and indirect fine particles (2.5 micrometers in diameter or smaller) produced from emissions of sulfate and nitrite gases, volatile organic compounds and ammonia, plus ozone, toxic air pollutants, emissions to surface and ground water, and emissions to soil.

“We found that for the vehicle operation phase of our LCIA, the annual health damages avoided in the US with 10-percent less gasoline-run motor vehicle emissions ranges from about 5,000 to 20,000 DALY, with most of the damage resulting from primary fine particle emissions,” said McKone.

“While county-specific damages range over nine orders of magnitude across all US counties most of the damage, as you would expect, is concentrated in urban populations with the highest impact in the Los Angeles, New York and Chicago regions,” he added. (ANI)

Study says pregnant women who exercise give birth to healthy babies

According to the findings of the researchers of the Kansas City University of Medicine and Biosciences, mothers-to-be who exercise during their pregnancy term give birth to healthy babies, with their lungs and nervous system strengthened in the womb.

In addition, exercise during pregnancy also helps women reduce the chances of sudden infant death syndrome (SIDS) or cot deaths. Researchers say that, if pregnant women remain physically active, the babies in their wombs not only have lower heart rates but also show improved breathing.

The study’s lead researcher, Dr Linda May, assistant professor of anatomy at Kansas City University, said since the reason behind SIDS is a weak nervous system; exercise in pregnancy serves as an “early intervention” for averting cot deaths.

Elaborating further, Linda May said: “We tested foetal breathing movement and the way the baby’s nervous system was developing. When we compared babies whose mothers exercised with babies whose mothers had not exercised, we found wonderful differences. Foetal breathing movement and the nervous system were more mature in babies exposed to exercise.”

To arrive at the “exciting” results, the researchers observed 36 to 38 weeks pregnant women, in the age group of 20 to 35 years. The women were categorized as exercisers if they spent at least half-an-hour thrice a week on exercising – the most common ones being aerobics, power-walking, and cycling!

Exercise during pregnancy could boost baby’s health

London, Apr 17 (ANI): Pregnant women could strengthen their babies’ lungs and nervous system by exercising, new research suggests.

American researchers conducted a small study into the impact of exercise and found potential benefits for unborn babies.

According to scientists, exercise may also help prevent cot death.

Dr Linda May, an assistant professor of anatomy at Kansas City University of Medicine and Biosciences, said her study had yielded “exciting” results.

“We tested foetal breathing movement and the way the baby’s nervous system was developing,” The Scotsman quoted her, as saying.

“When we compared babies whose mothers exercised with babies whose mothers had not exercised, we found wonderful differences.

“Foetal breathing movement and the nervous system were more mature in babies exposed to exercise,” she added.

All the women involved in the study were 36 to 38 weeks pregnant and aged 20-35. The mothers-to-be were classified as exercisers if they exercised for at least 30 minutes three times a week. ANI)