Run a marathon to arrest cellular suicide

Washington, May 11 (ANI): Running a marathon can halt apoptosis, the natural ”programmed” death of cells, a new study has found.

Gabriella Marfe from the University of Rome ”Tor Vergata” led a team of researchers who studied ten amateur athletes after a 42km run.

The team studied peripheral blood mononuclear cells (PBMCs), isolated from whole blood samples taken from people after finishing a marathon, finding that the balance between expression of pro- and anti-apoptotic genes is shifted after the race.

“Apoptosis is a normal physiological function dependent on a variety of signals, many of which can be modulated by strenuous exercise. Here, we”ve shown for the first time that exercise modulates expression of the sirtuin family of proteins, which may be key regulators of training,” Marfe said.

The scientists believe that the sirtuin family of proteins, particularly SIRT1, may be involved in the protective effects of exercise against cell death.

Talking about the study”s findings, Marfe said: “Sirtuins may play a crucial role of mediators/effectors in the maintenance of skeletal and cardiac muscle tissues as well as neurons, thus explaining the synergic protective effects of physical exercise and calorie restriction for survival and ageing”.

However, the researchers also caution that any exercise people carry out should be done properly.

Marfe said: “Untrained amateur athletes often do hard training without professional advice. Such intense and exhaustive exercise can be harmful to health. In order to achieve beneficial effects, we recommend that exercise training should form part of a lifelong regime with expert medical advice and supervision”.

The study has appeared in the open access journal BMC Physiology. (ANI)

Scientists isolate microalgal strain that could reduce cholesterol

Washington, May 4 (ANI): Scientists in Israel have isolated a microalgal strain, which produces large amounts of a polyunsaturated fatty acid that could reduce blood pressure, chronic inflammation and blood cholesterol level, reducing the risk for heart attacks.

A team of researchers from Ben-Gurion University of the Negev (BGU), headed by Prof. Zvi HaCohen, is studying an algal mutant that is capable of accumulating up to 15 percent (of dry weight) of a polyunsaturated fatty acid (PUFA) called DGLA (Dihomo-ã-Linolenic Acid).

The new strain, IKG-1, is a freshwater microalga that the researchers believe is the only known plant source capable of producing such significant amounts of DGLA.

“Omega-6 PUFA are necessary as components of brain cell membranes and have various nutritional uses. DGLA is one of these PUFA, but appears in nature only as an intermediate in the biosynthesis of other compounds and does not accumulate to any appreciable concentration. There is no natural source for DGLA and although its beneficial effects are well known, very few clinical studies have been conducted,” said HaCohen. (ANI)

Regular aspirin use raises risk of Crohn”s disease by 5 times

Washington, May 4 (ANI): People who take aspirin regularly for a year or more could be increasing their risk of developing Crohn”s disease, says a new study.

The study by University of East Anglia (UEA) will be presented for the first time at the Digestive Disease Week conference in New Orleans.

Crohn”s disease is characterized by inflammation and swelling of any part of the digestive system. This can lead to debilitating symptoms and requires patients to take life-long medication. Some patients need surgery and some sufferers have an increased risk of bowel cancer.

Though there are likely to be many causes of the disease, previous work on tissue samples has shown that aspirin can have a harmful effect on the bowel.

To investigate this potential link further, the UEA team followed 200,000 volunteers aged 30-74 in the UK, Sweden, Denmark, Germany and Italy. The volunteers had been recruited for the EPIC study (European Prospective Investigation into Cancer and Nutrition) between 1993 and 1997.

The volunteers were all initially well, but by 2004 a small number had developed Crohn”s disease. When looking for differences in aspirin use between those who did and did not develop the disease, the researchers discovered that those taking aspirin regularly for a year or more were around five times more likely to develop Crohn”s disease.

The study also showed that aspirin use had no effect on the risk of developing ulcerative colitis – a condition similar to Crohn”s disease.

“This is early work but our findings do suggest that the regular use of aspirin could be one of many factors which influences the development of this distressing disease in some patients,” said lead researcher Dr Andrew Hart of UEA”s School of Medicine.

“Aspirin does have many beneficial effects, however, including helping to prevent heart attacks and strokes. I would urge aspirin users to continue taking this medication since the risk of aspirin users possibly developing Crohn”s disease remains very low – only one in every 2000 users, and the link is not yet finally proved.” (ANI)

Brain estrogen drug an ‘effective therapy’ for schizophrenics

Washington, Mar 31 (ANI): Raloxifene, a synthetic estrogen currently used to treat osteoporosis, is showing promise as an effective therapy for women who suffer from schizophrenia, it has been claimed.

Raloxifene, which influences neurotransmitter and neuronal systems in the brain, has beneficial effects on postmenopausal women with schizophrenia, with a test group experiencing a more rapid recovery from psychotic and other symptoms compared to control groups.

Research project leader and Director of the Monash Alfred Psychiatry Research Centre (MAPrc) Professor Jayashri Kulkarni said women in the trial who were given 120mg a day of the unique selective estrogen receptor modulator had a significantly greater improvement in psychosis symptoms compared with those on placebos and lower doses.

“The results were very promising. Under daily treatment with this ”brain estrogen”, the women in the study had improvement in their key psychosis symptoms and also experienced enhanced memory and higher learning capacity,” Professor Kulkarni said.

“Many patients in this study had longstanding, persistent schizophrenia, so we are delighted that they experienced improvements in their mental well-being. We will continue to investigate the efficacy of Raloxifene which is a currently available treatment for osteoporosis in postmenopausal women.”

“Unlike estradiol, the standard estrogen found in the oral contraceptive pill or hormone replacement treatment, this type of estrogen did not have the side effects on breast, uterus and ovarian tissue that we worry about with other forms,” Professor Kulkarni said.

While the findings were still tentative given the relatively small sample size, the research team is cautiously optimistic that ongoing trials will further confirm the positive therapeutic potential of the drug for postmenopausal women, and potentially for other cohorts.

The findings have been published in Psychoneuroendocrinology. (ANI)

Could erectile dysfunction drugs help muscular dystrophy patients?

Washington, Mar 25 (ANI): Taking a step further from a recent rodent study, a Cedars-Sinai Heart Institute cardiologist is probing if drugs used to treat erectile dysfunction could also be used to improve muscle blood flow and reduce fatigue in muscular dystrophy patients.

A recent study showed beneficial effects of tadalafil (also known as Cialis) in mice with an animal version of Duchenne and Becker muscular dystrophy.

Only two doses of tadalafil improved muscle blood flow, allowing the dystrophic mice to perform more exercise with less muscle injury.

The new short-term clinical trial will move the testing from animals to human patients with Becker muscular dystrophy and examine the effects of acute tadalafil dosing on muscle blood flow during a bout of exercise.

Patients will take two doses of tadalafil prior to exercising. Then doctors will measure whether muscles receive increased blood flow and therefore are better protected during exercise.

“This is an exciting next step in the research I have been doing for 25 years, because we don’t need to create a new drug — the drug already exists. We now have the opportunity to find out if tadalafil can offer some hope for improving the lives of patients and allow them to do more exercise with less muscle injury,” said Victor.

The study is open to adult males 18 – 55 who have Becker muscular dystrophy as well as adult males who don’t have it.

And it includes includes hand grip exercise testing, measurements of muscle blood flow and oxygen delivery, and magnetic resonance imaging of the muscles. (ANI)

Moderate alcohol consumption is good for sick hearts

Washington, Mar 23 (ANI): Regular and moderate alcohol consumption is beneficial for people who had a previous heart attack or other ischemic vascular events, a new study has concluded.

The study was performed by the Research Laboratories at the Catholic University of Campobasso, Italy. It claimed that moderate consumption, defined as one or two glasses of wine a day or the equivalent amounts of beer or other alcoholic beverages, significantly reduces the risk of death from any cause in those who already suffered from ischemic vascular disease.

The research, published in the Journal of the American College of Cardiology (JACC), was performed using the statistic procedure of meta-analysis which allows to combine different studies conducted worldwide to achieve more precise results.

Researchers analyzed the most important scientific studies performed during the last years. Eight in total in four Countries: United States, Sweden, Japan and Great Britain. Each study took into account patients already affected by an ischemic vascular event. During the years following the disease onset, patients were followed by researchers to know which were the lifestyle habits, including alcohol consumption, able to avoid a new clinical event. The meta-analysis allowed to pool all those studies for a total of 16,351 people examined.

“We observed,” says Simona Costanzo, epidemiologist and first author of the study, “that regular and moderate consumption has beneficial effects even for people already affected by heart attack, or stroke. Not only they are less likely to be affected by similar diseases again, but all-cause mortality too resulted to be lower than in those who did not consume any alcoholic beverage”.

The effect is very similar to that observed in healthy people. “Risk reduction”, Costanzo argues, “is about 20 percent. This means that one event out of five can be spared. It is a huge advantage, comparable to the one already recorded for healthy individuals”.

“When we talk about moderate alcohol consumption, we mean something quite far from what we use to see in TV fictions,” says Licia Iacoviello, Head of the Laboratory of Environmental and Genetic Epidemiology and responsible of the Moli-sani Project. “We refer to moderation as drinking regularly, at low doses, within a healthy lifestyle, such as the Mediterranean diet. A glass of wine or beer during meals has always been an integral part of the Mediterranean way of eating. Our research highlights another crucial issue: drinking has not only to be moderate, but also regular. A moderate consumption spread along the week is positive. The same amount of weekly alcohol, concentrated in a couple of days is definitely harmful”. (ANI)

Three cups of tea a day can cut diabetes risk by almost half

London, Sept 19 (ANI): Intake of at least three cups of tea every day can reduce the risk of diabetes by almost half, concludes a new study.

To reach the conclusion, researchers studied more than 40,000 people whose consumption was monitored for 10 years.

After analyses, boffins discovered that chemicals found in all types of tea cut the dangers of developing type 2­diabetes by 42 per cent. Drinking more than three cups did not reduce the risk any further, reports The Daily Express.

The study was carried out by a team of Dutch researchers from the University Medical Centre in Utrecht.

The team concluded: “Consumption of at least three cups of tea and/or coffee was associated with a lowered risk of type 2 diabetes. Blood pressure and intake of magnesium, potassium and caffeine did not explain these associations.”

Instead, the beneficial effects in tea were probably explained by “flavonoid antioxidants” which are found in every cup.

Dr Carrie Ruxton, of Britain’s Tea Advisory Panel, said: “The study did not distinguish between black and green tea, but 95 per cent of tea drunk in the Netherlands is black tea, that is regular tea. The results remained the same even when the researchers accounted for other factors which might have influenced diabetes risk, such as body mass index, blood pressure, caffeine, dietary magnesium and potassium.

“This suggests that ingredients other than caffeine, magnesium and potassium (all found in tea) could be causing the beneficial effect. Likely candidates are the flavonoid antioxidants found in tea which are known to protect body cells from damage.” (ANI)

Green tea may help improve bone health

Washington, Sept 17 (ANI): Green tea may help improve bone health, researchers in Hong Kong have reported.

The boffins found that the tea contains a group of chemicals that can stimulate bone formation and help slow its breakdown.

The study has been published in ACS’ Journal of Agricultural and Food Chemistry, a bi-weekly publication.

In the study, Ping Chung Leung and colleagues noted that many scientific studies have linked tea to beneficial effects in preventing cancer, heart disease, and other conditions.

To reach the conclusion, scientists exposed a group of cultured bone-forming cells (osteoblasts) to three major green tea components – epigallocatechin (EGC), gallocatechin (GC), and gallocatechin gallate (GCG) – for several days. They found that one in particular, EGC, boosted the activity of a key enzyme that promotes bone growth by up to 79 percent. EGC also significantly boosted levels of bone mineralization in the cells, which strengthens bones.

The scientists also showed that high concentrations of ECG blocked the activity of a type of cell (osteoclast) that breaks down or weakens bones. The green tea components did not cause any toxic effects to the bone cells, they noted. (ANI)

Kudzu extract shows promise as dietary supplement for metabolic syndrome

Washington, Sep 4 (ANI): Kudzu, the nuisance vine that has overgrown almost 10 million acres in the southeastern United States, can be used as a dietary supplement for metabolic syndrome.

Scientists in Alabama and Iowa have found that root extracts from kudzu show promise as a dietary supplement for metabolic syndrome that increases the risk of obesity, high blood pressure, high blood cholesterol, and problems with their body”s ability to use insulin.

Those disorders mean a high risk for heart attacks, strokes, and other diseases.

Lead researcher J. Michael Wyss showed that kudzu root extract contains healthful substances called isoflavones.

People in China and Japan have long been using kudzu supplements as a health food.

The study found that a kudzu root extract had beneficial effects on lab rats with metabolic syndrome.

After two months of taking the extract, the rats had lower cholesterol, blood pressure, blood sugar, and insulin levels that a control group not given the extract.

Kudzu root “may provide a dietary supplement that significantly decreases the risk and severity of stroke and cardiovascular disease in at-risk individuals,” the article notes.

The study appears in Journal of Agricultural and Food Chemistry. (ANI)

Kudzu extract shows promise as dietary supplement for metabolic syndrome

Washington, Aug 27 (ANI): Kudzu, the nuisance vine that has overgrown almost 10 million acres in the southeastern United States, can be used as a dietary supplement for metabolic syndrome.

Scientists in Alabama and Iowa have found that root extracts from kudzu show promise as a dietary supplement for metabolic syndrome that increases the risk of obesity, high blood pressure, high blood cholesterol, and problems with their body’s ability to use insulin.

Those disorders mean a high risk for heart attacks, strokes, and other diseases.

Lead researcher J. Michael Wyss showed that kudzu root extract contains healthful substances called isoflavones.

People in China and Japan have long been using kudzu supplements as a health food.

The study found that a kudzu root extract had beneficial effects on lab rats with metabolic syndrome.

After two months of taking the extract, the rats had lower cholesterol, blood pressure, blood sugar, and insulin levels that a control group not given the extract.

Kudzu root “may provide a dietary supplement that significantly decreases the risk and severity of stroke and cardiovascular disease in at-risk individuals,” the article notes.

The study appears in Journal of Agricultural and Food Chemistry. (ANI)

Bone marrow extract therapy after heart attack improves cardiac function

Washington, June 30 (ANI): A new study has found that an extract derived from bone marrow cells is as effective as therapy using bone marrow stem cells for improving cardiac function after a heart attack.

The study was conducted in mice using a novel stem cell delivery method developed by researchers to show that the extract from bone marrow cells is as beneficial to cardiac function as are intact, whole cells.

Both the cell and cell extract therapies resulted in the presence of more blood vessels and less cardiac cell death, or apoptosis, than no therapy.

The study also showed that heart function benefitted despite the finding that few of the injected cells remained in the heart at one month after therapy.

“Peer-reviewed medical literature is controversial as to whether bone marrow cells differentiate into cardiomyocytes, or cardiac muscle cells, but there is general agreement that stem cell therapy with these cells results in some level of functional improvement after a heart attack. The exact mechanism for this is not yet clear,” said Yerem Yeghiazarians, MD, study author, cardiologist and director of UCSF’s Translational Cardiac Stem Cell Development Program.

“Our results confirm that whole cells are not necessarily required in order to see the beneficial effects of bone marrow cell therapy,” Yeghiazarians added.

Researchers are investigating these new therapies to improve cardiac function after heart attack in an effort to prevent heart failure.

“Current therapies improve symptoms but do not replace scar tissue. Our hope is to use stem cells to decrease the scar, minimize the loss of cardiac muscle and maintain or even improve the cardiac function after a heart attack,” Yeghiazarians said.

The researchers are conducting further studies to evaluate bone marrow cell and extract therapies in order to identify the proteins and factors within the extract and gain insight into the possible mechanisms of cardiac functional improvement.

The findings were published online and in the July 2009 issue of the Journal of Molecular Therapy. (ANI)

Chewable aspirin gets more rapidly absorbed than regular aspirin

Washington, May 15 (ANI): Analysing three different types of aspirin for their beneficial effects, scientists at the University of California, San Diego have come up with a finding that may lead to improvements in the care of heart attack patients.

Lead researcher Dr. Sean Nordt has revealed that the three types of aspirin given to a group of volunteer were regular aspirin swallowed whole, regular aspirin chewed and swallowed, and chewable aspirin chewed and swallowed.

The team then measured blood levels of aspirin to see which route led to the highest aspirin levels in the body.

They found that the chewable aspirin consistently showed greater and more rapid absorption than the regular aspirin, whether swallowed whole or chewed.

Dr. Nordt made a presentation on the team’s findings at the 2009 SAEM Annual Meeting at the Sheraton New Orleans recently.

The study has been reported in the journal Academic Emergency Medicine. (ANI)

Traditional Chinese herb may help make immunological drugs

Washington, May 14 (ANI): A herb called ginseng, which has long been used in traditional Chinese and other Asian medicine, naturally contains anti-inflammatory effects that may be harnessed to make immunological medications, according to a study.

Led by Allan Lau, a team of researchers from the University of Hong Kong conducted laboratory experiments and identified seven ginseng constituents, ginsenosides, which showed immune-suppressive effects.

“The anti-inflammatory role of ginseng may be due to the combined effects of these ginsenosides, targeting different levels of immunological activity, and so contributing to the diverse actions of ginseng in humans,” said Lau.

Treating human immune cells with different extracts of ginseng, the researchers found that out of the nine ginsenosides they had identified, seven could selectively inhibit expression of the inflammatory gene CXCL-10.

Lau concluded: “Further studies will be needed to examine the potential beneficial effects of ginsenosides in the management of acute and chronic inflammatory diseases in humans.”

Taking a unique approach, the researchers could holistically test the ginseng extract’s immune effects by using sophisticated purification technologies to identify individual constituents, and define their bioactivity using genomics and bioactivity assays.

The team then reconstituted them back into a whole extract with definable individual ginsenosides for re-confirmation of effects.

Thus, the findings open up the doors towards a vigorous methodology to study medicinal herbs with state-of-the-art technologies.

The study has been published in BioMed Central’s open access Journal of Translational Medicine. (ANI)

Vitamin E, C supplements may reduce benefits of exercise

Washington, May 12 (ANI): A new study suggests that some vitamin supplements may reduce some of the beneficial effects of exercise.

Michael Ristow, of the University of Jena in Germany, has shown that antioxidant supplements like vitamin C or E can interfere with the benefits of exercising.

Previous studies have also revealed that taking antioxidants may hasten death through an unknown mechanism.

One possibility, according to the researcher, is that they interfere with the beneficial effects of exercise, as there are hints that free radicals might be used by the body to prevent cellular damage after exercise.

During the study, the researchers recruited 40 volunteers. Half of them were asked to take 1000 milligrams of vitamin C and 400 international units of vitamin E per day – equivalent to amounts in some vitamin supplements.

The volunteers were also asked to exercise for 85 minutes a day, five days a week, for four weeks.

The researchers found that muscle biopsies showed a two-fold increase in a marker of free radicals called TBARS (thiobarbituric acid-reactive substances) in those volunteers who didn’t take antioxidants

However, they found no increase in those who did take the supplements – suggesting that they were indeed mopping them up.

Ristow pointed out that exercise is well known to have a beneficial effect on insulin resistance – a precursor condition to type 2 diabetes.

However, when the team measured the effects of exercise on insulin sensitivity, they found no increase in those volunteers taking antioxidants, but a significant increase in those who didn’t take the supplements.

“These data are fully in accord with recent work on the actions of reactive oxygen species in cells, although clearly at odds with the popular concept that dietary antioxidants are inevitably beneficial,” New Scientist magazine quoted Malcolm Jackson at the University of Liverpool, UK, who was not involved in the research as saying.

In fact, in this case, “antioxidants are preventing the health effects of exercise,” said Ristow,

He, however, cautions that not all vitamin supplements contain such high doses of vitamin C and E.

The study appears in Proceedings of the National Academy of Sciences. (ANI)

Combo therapy of vitamin E, selenium, soy doesn’t prevent prostate cancer

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Washington, April 27 (ANI): A new study, conducted by Canadian researchers, has found that the combination therapy of vitamin E, selenium and soy does not prevent the progression from high-grade prostatic intraepithelial neoplasia (HGPIN) to prostate cancer./pp
For the study, researchers divided 303 men, with an average age of 62, into two randomized groups. /pp
All participants had HGPIN, a precursor to invasive prostate cancer, as confirmed by a central pathology review in at least one of two biopsies within 18 months prior to randomization. /pp
The combination treatment was administered daily for three years with follow-up prostate biopsies at six, 12, 24 and 36 months. Supplementation was discontinued if a man developed invasive disease. /pp
Researchers found that 26.4 percent of patients developed invasive prostate cancer. Baseline, age, weight and testosterone levels did not predict the development of cancer. /pp
Unfortunately, as this study shows, we have yet to find a dietary supplement that will reliably prevent prostate cancer. The results of this study support the findings of the SELECT trial which also demonstrated no benefit using Vitamin E and selenium, said Christopher Amling, MD, an AUA spokesman. /pp
These studies highlight the importance of conducting randomized trials of these agents since many of these supplements are promoted falsely to the general public as having beneficial effects on cancer prevention and progression, he added./pp
The findings were presented at the 104th Annual Scientific Meeting of the American Urological Association (AUA). (ANI)/p

Drinking coffee could lower stroke risk for women

Boston/Berlin – Women who enjoy drinking coffee may be lowering their risk of suffering a stroke, new US research suggests. Women who drank five to seven cups of coffee a week were 12 per cent less likely to have a stroke than were those who downed just one cup a month, the study among 83,000 women revealed.

The survey was carried out over a 24-year period by Harvard Medical School and Harvard School of Public Health in Boston and the findings published in the March issue of the journal Circulation.

According to the German experts on stroke prevention in Berlin, the benefit does not appear to come from caffeine. Those who drank tea and other caffeinated drinks did not experience the same reduction in stroke risk, said Professor Martin Grond of the German Stroke Society.

It seems the positive health effects of coffee-drinking come from antioxidants in the beverage which lower inflammation and improve blood vessel function.

Taking into consideration factors such as cigarette and alcohol consumption, researchers found that healthy women who drank two to three cups of normal caffeinated coffee a day had, on average, a 19 per cent lower risk for any kind of stroke than did women who drank less than one cup a month. Drinking four or more cups a day lowered the risk by 20 per cent.

At the same time, the study confirmed that the beneficial effects of coffee only apply to otherwise healthy people. Those with complaints such insomnia, anxiety, high blood pressure and cardiac complications should be aware that coffee consumption was likely to worsen their condition, said Grond. (dpa)

Drinking coffee could reduce stroke risk for women

Sydney, April 13 (ANI): Drinking coffee could lower women’s risk of suffering a stroke, a new study has suggested.

The study of 83,000 women, conducted over a 24-year period by Harvard Medical School and Harvard School of Public Health in Boston, revealed that women who drank five to seven cups of coffee a week were 12 per cent less likely to have a stroke than were those who downed just one cup a month.

However, German experts on stroke prevention in Berlin say that the benefit does not appear to come from caffeine, reports the Sydney Morning Herald.

Professor Martin Grond of the German Stroke Society said that those who drank tea and other caffeinated drinks did not experience the same reduction in stroke risk.

It looks like the positive health effects of coffee-drinking come from antioxidants in the beverage, which lower inflammation and improve blood vessel function, according to researchers.

Taking into consideration factors such as cigarette and alcohol consumption, researchers found that healthy women who drank two to three cups of normal caffeinated coffee a day had, on average, a 19 per cent lower risk for any kind of stroke than did women who drank less than one cup a month.

They found that drinking four or more cups a day lowered the risk by 20 per cent.

Meanwhile, the study confirmed that the beneficial effects of coffee only apply to otherwise healthy people.

Grond warned that those with complaints such insomnia, anxiety, high blood pressure and cardiac complications should be aware that coffee consumption was likely to worsen their condition.

The study has been published in the March issue of the journal Circulation. (ANI)

How gut bacteria prevents cancer, inflammatory bowel disease in humans

Washington, Feb 6 (ANI): In a new study, researchers have found that bacteria present in the gut can release substances that may protect the body against colon cancer and inflammatory bowel disease.

Scientists at the University of Aberdeen Rowett Institute of Nutrition and Health and from the MTT Agrifood Research Institute in Finland showed that bacteria in the human gut convert linoleic acid, a naturally-occurring fat in the diet, into a form called conjugated linoleic acid (CLA) which is absorbed by the gut wall.

Dr John Wallace of the Rowett Research Institute said that there exist different types of CLA, out of which only a few have beneficial effects, and that “good” form of CLA is present in dairy foods such as milk and cheese.”

“But eating lots of dairy foods won’t necessarily help our gut health as most of the fats are digested in the small intestine before they get to the large intestine, where most of our gut bacteria are found,” he said.

The findings indicated that gut bacteria produce several different forms of CLA, most of which are of the “good” kind.

Bit Wallace stressed that more extensive studies are needed, as one subject produced small amounts of a CLA whose effects are much less clear.

Thus, the researchers deduced that if small quantities of dietary linoleic acid could be delivered to the large intestine, the effects on gut health would be generally beneficial in most people.

“The results are of special interest for individuals using anti-obesity treatments that prevent the small intestine from absorbing fats. This means that those fats – including linoleic acid – will pass into the large intestine and the gut bacteria will produce CLA. It has to be the correct CLA, so it is important to understand how individuals produce different CLA. This must depend on which types of bacteria are present,” said Wallace.

The study has been published in the journal Microbiology. (ANI)