New air filter system can destroy up to 99.9 per cent of bugs on aircraft

London, September 16 (ANI): British researchers have developed an air filter system that destroys up to 99.9 per cent of infectious viruses and bacteria as well as pollutants that can circulate in the confines of an aircraft, especially on long-haul flights.

According to a report in The Times, the machine has been developed by aerospace giant BAE Systems, in collaboration with Quest International, a small company based in Cheadle, South Manchester, UK.

The device, called AirManager, uses a controlled electric field to filter out and destroy any airborne particles or germs as they pass through an aircraft’s air conditioning system, emitting only clean, sterilized air.

After four years of development and tests, BAE says it has received its first orders from a major European airline and announced the technology is also being considered for use in NHS hospitals as a way to stop the spread of “superbugs” such as MRSA and Clostridium difficile.

The air on board a passenger jet must be pressurized in order for passengers to be able to breathe, but scientists and lobby groups have previously claimed that passengers can be exposed to toxins as a result of the “bleed air” system that is used to redirect air from the engines to the cabin and cockpit.

Air inside the cabin is then circulated and re-circulated up to 30 times an hour, far more than in conventional air conditioning systems, meaning that infectious viruses and bacteria can quickly spread.

Unlike conventional filters, which are designed to sieve out particles from the air as it passes through perforated barriers at high speed, David Hallam, an engineer and founder of Quest International, said that the AirManager used an “avalanche of electrons” emitted in a closed electric field to break down and destroy the atomic structure of any pollutants or germs.

“This works with swine flu, avian flu, norovirus, MRSA, even a modified form of anthrax,” Hallam said.

Hallam said that he originally designed the “close coupled field” in the late 1990s to rid nursing homes of biological odours caused by bacteria.

But, the filter was later found to have an effect in reducing the airborne transmission of bacteria such as MRSA (methicillin-resistant Staphylococcus aureus) and Clostridium difficile.

BAE Systems expressed interest in the technology four years ago for use on aircraft and the system was recently tested on the flight deck and cabin air systems of Boeing 757 and Avro RJ passenger jets by five European airlines, with successful results. (ANI)

Mozart ‘killed by superbug like MRSA, not poison’

London, Aug 18 (ANI): Austrian composer Wolfgang Amadeus Mozart was killed by a bacterial infection akin to MRSA, claim Dutch researchers.

Mozart died at age 35 – young by even 18th century standards. His untimely death has remained a mystery ever since he passed away in the early hours of 5 December 1791.

Some claimed he was poisoned, others said he simply wore himself out by composing more than 600 pieces during his short life.

Now, a group of boffins has suggested that he died from a bacterial infection spread by soldiers which was rife in Vienna at the time, reports The Telegraph.

The researchers, who studied the city’s death register, found that the three most common causes of death among men of his age were tuberculosis, severe weight loss and a condition called ‘oedema’ or ‘dropsy’ – an accumulation of fluids causing the body to swell up.

And, Mozart’s symptoms match the last of the three, according to Dr Richard Zeger, from the Academic Medical Centre in Amsterdam, who said it could have been caused by a bacterial infection.

He said: “I think you can compare this to a superbug like MRSA or C.difficile.”

Mozart’s sister-in-law Sophie Haibel, who saw him days before he died, said he was covered in a rash – consistent with a bacterial infection – and severely swollen – consistent with oedema or dropsy.

At the time Vienna was full of soldiers from the Austro-Turkish war who had been struck down by disease.

Zeger said: “Austria was at war at the time so people were living in a bad condition and most of the deaths were among soldiers. You can see there was clearly an epidemic and we found that it started in a military hospital. There was some kind of inflammatory disease that almost everyone contracted and some people died. It was an epidemic of oedema, which is a collection of fluid.

“When your kidneys fail, they can’t secrete body fluids so fluid accumulates in your body, which causes people to swell up and get worse and worse.”

This kind of a condition could have been caused by being infected with bacteria from the Staphylococcus aureus (SA) family, or which MRSA is a more recent member.

“Mozart’s body had swollen up so badly he was not able to turn around any more in his bed, showing he had post-streptococcal complications,” said Zeger.

In those times, antibiotics like penicillin were nowhere present, so strictly speaking the bacteria would not have been a ‘super’ bug as it could not have developed any resistance in the way that methicillin-resistant Staphylococcus aureus (MRSA) has done.

Zeger postulated: “We still see the streptococcal infection today in close communities like schools and armies so that would be a good reason behind the epidemic.

“In Mozart’s time, several soldiers in the army were also musicians who might have performed in Vienna, where Mozart might have contracted it.” (ANI)

Genetic mapping shows how staph infections disrupt immune system

Washington, July 14 (ANI): Researchers have used genetic mapping to explain how the human immune system is programmed to respond to Staphylococcus aureus infections.

Infectious disease specialists at UT Southwestern Medical Center have mapped the gene profiles of children with severe S. aureus infections, to see how the pathogen alters the human immune system.

The findings of the study could open new doors for improved therapeutic interventions.t has long been unknown how the host’s immune system responded to S. aureus infection, and why some individuals are more vulnerable towards severe staphylococcal infections than others.

“The beauty of our study is that we were able to use existing technology to understand in a real clinical setting what’s going on in actual humans – not models, not cells, not mice, but humans. We have provided the first description of a pattern of response within an individual’s immune system that is very consistent, very reproducible and very intense,” said Dr. Monica Ardura, lead author of the study.

The immune system consists of two components- the innate system, which provides immediate defense against infection, and the adaptive system, whose memory cells are called into action to fight off subsequent infections.

During the study, the researchers extracted ribonucleic acid from a drop of blood, and placed it on a special gene chip called a microarray, which probes the entire human genome to determine which genes are turned on or off.

It was found that in children with invasive staphylococcal infections, the genes involved in the body’s innate immune response are overactivated while those associated with the adaptive immune system are suppressed.

“It’s a very sophisticated and complex dysregulation of the immune system, but our findings prove that there’s consistency in the immune response to the staphylococcus bacterium. Now that we know how the immune system responds, the question is whether we can use this to predict patient outcomes or differentiate the sickest patients from the less sick ones. How can we use this knowledge to develop better therapies?” said Ardura.

The researchers used blood samples collected between 2001 and 2005 from 77 children – 53 hospitalized at Children’s Medical Center Dallas with invasive S. aureus infections and 24 controls.

Ardura claimed that more research was needed because the results represented a one-time snapshot of what’s going on in the cell during an invasive staphylococcal infection.

The researchers are now hoping to understand better how various staph-infection therapies affect treatment.

The study is available online in PLoS One, the Public Library of Science’s online journal. (ANI)

Tea tree oil, silver combo can make for effective antiseptics

Washington, Mar 30 (ANI): A combination of tea tree oil and silver can make for an effective antiseptic for skin wounds, says a new study.

The research team led by Wan Li Low from the University of Wolverhampton showed that mixing tea tree oil and silver (in the form of silver nitrate) or putting them in liposomes, (small spheres made from natural lipids), greatly increases their antimicrobial activity and minimise side effects.

During the study, the researchers found that low concentrations of two agents significantly increased their antimicrobial activity.

They focused on bacteria such as Staphylococcus aureus and the yeast Candida albicans, which cause skin infections.

To reach the conclusion, researchers used microscopic spherical bodies called liposomes, made of phospholipids, the naturally occurring lipids or fats in the cell wall membranes, to deliver the silver and tea tree oil mix to infected wounds.

This lead to a controlled release and therefore, a potential to use lower, less toxic, concentrations of the antimicrobial agents to treat infected wounds.

It can also be used for treating antibiotic resistant strains such as MRSA.

Current treatments using traditional silver-based creams and dressings use relatively high metal concentrations.

The creams containing lower amounts of the agents could provide safer and readily available over-the-counter antiseptic compounds for effective treatment without damaging the surrounding skin.

The findings are to be presented at the Society for General Microbiology meeting in Harrogate. (ANI)

Infection control strategies for antibiotic-resistant organisms in hospitals

Washington, Mar 16 (ANI): Hand-washing, a clean environment, appropriate infection barriers, and early identification of patients at high risk of colonization with a transmissible microorganism are some of the infection control strategies adopted by hospitals for antibiotic-resistant organisms.

A review of the control strategies has revealed the above measures after looking at the most effective methods, and the supporting evidence to control hospital infection.

Risk factors associated with colonization of antibiotic-resistant microorganisms include increasing age of patient and severity of disease, increasing length of hospital stay, admission to an intensive care unit, and proximity to patients carrying an antimicrobial-resistant organism.

Use of broad-spectrum antibiotics and/or prolonged use of antibiotics are also risk factors.

Methicillin-resistant Staphylococcus aureus (MRSA), Clostridium difficile (C.difficile), and vancomycin-resistant enterococci are the most common antimicrobial-resistant pathogens.

Resistance is more prevalent in hospital-acquired infections compared to community-acquired infections.

The detailed review is published in the latest issue of CMAJ. (ANI)