Patrick Dempsey joins coming-of-age film

LOS ANGELES (Hollywood Reporter) – “Grey’s Anatomy” heartthrob Patrick Dempsey is attached to star in “Tom’s Dad,” a coming-of-age film written by New York playwright Marty Casella.

Film

The story unfolds in 1962 Las Vegas, as a successful character actor and vaudevillian nightclub performer struggles to keep up with changing comedy styles as his estranged son appears to complicate matters.

It will be directed by Lasse Hallstrom (“Dear John”) and produced in part by Johnny Depp’s Infinitum Nihil production company.

Dempsey most recently starred in “Enchanted,” “Made of Honor” and “Valentine’s Day.”

Elephants’ legs work like four-wheel drive in a car!

London, Mar 30 (ANI): Elephants move like a 4×4 vehicle with all four legs used to accelerate and brake, boffins have found.

In their research, scientists discovered that elephants eliminate the separation of functions of the front and back legs despite having an anatomy very similar to other four-legged animals.

Power is applied independently to each limb, reports The Daily Express.

Other animals that walk on all fours use the hind limbs for power and their forelegs for braking.

“Elephant legs function in very strange and probably unique ways,” said Dr John Hutchinson, of the Royal Veterinary College, London.

Earlier it was thought that elephants needed rigid pillar-like legs to support their weight but in fact they flex like humans. (ANI)

Forensics database set up in Perth

Researchers in Perth are building a database of skeletons to help identify bodies more quickly and accurately.

The University of Western Australia has been given a $400,000 grant for the project, which involves mapping the shape and co-ordinates of bones.

Assistant Professor Daniel Franklin has told WA’s Stateline program, police will then use the database to identify specific features of skeletons such as the age, sex and ethnicity.

“They could digitise various parts of the skeleton whether it be the skull, hip bone or various leg bones, we should have data for all of that,” he said.

“The police should be able to get an answer as to whether the individual was a male or a female, potentially how old they were.”

WA Police Superintendent, Haydn Green, was in charge of identifying the victims in Phuket from the 2004 Boxing Day Tsunami.

He says the database will be extremely helpful in the future.

Shocking tapes reveal what MJ really thought about his family

London, September 20 (ANI): Michael Jackson had launched a string of verbal attacks on his family in secret taped interviews, it has emerged.

The King of Pop lashed out at his brothers Jackie, Tito, Jermaine, and Marlon in the Jackson 5, calling them lazy moaners and dubbing them, one by one, as dull, a copycat, a womaniser and argumentative.

The singer then went on to criticize sisters La Toya and Janet, and even called mum Katherine “disappointing” in the tapes recorded with the ghost writer of his autobiography Moonwalk, reports News of the World.

And after realising that he may have gone too far in his rants, Jackson snapped: “You can’t print that.”

He reportedly said: “The brothers didn’t give me support. We’d be working on a TV show or video and they’d be sitting around moaning and groaning but I’d be watching and learning. It takes a talent, but some people are lazy and don’t want to develop anything.”

On Tito: “Tito is into the anatomy of how a car is built. He is a grease monkey. He still goes to the hobby shop and buys airplanes and flys them. He loves putting them together – they’re on these plastic things and you glue them. That is so boring.”

On Marlon: “People used to call him ugly and make fun of him – and people would say, ‘Which brother is that one?’. He constantly imitates me on stage. Whatever I do he’ll do right after me. I hate when that happens because he looks too “doo woppy” and so old-fashioned.”

On Jermaine: “Jermaine would be either be looking for girls or going along with the jokes.”

On Jackie: “He approaches everything with so much negativity and doubting.”

On Randy: “He doesn’t listen and is real hard-headed. You say it’s dark – he’ll say it’s daylight. And he has to be macho. I’ll never forget the day we had a meeting with our producer who said you’ve got to stand up on your own. Randy stood up and said: “I’m a man’ – we are all started laughing.”

On his mum, whom he always insisted as “the closest person in his life, a great mother and provider”, he said: “She disappointed me. She did an interview (about him). I don’t like her to talk. It’s none of those people’s business.”

He added, “She wished she would have had all boys. She told my sisters that – and they agreed! That’s how my sisters are – they are prejudiced against other girls.”

On La Toya: “To me she is Mrs Nice and Nasty. I come in her room (and she says), ‘You can’t sit on her couch, sit on the bed or walk on the carpet’, She wants to keep everything fresh.

“If you cough at the table she covers her plate. If you sneeze forget it, she’s in another room. If you clear your throat, you can’t do that while she is eating. And forget about going to the movies. She doesn’t understand what I see in Star Wars, Close Encounters or Jaws.”

On Janet: “Janet is a tomboy. That is why it kills me to see her off and married. We did everything together and were just alike. We write a whole schedule for the day and follow it. It’s a terrible loss.”

On dad Joe: “I would suffer if I had to spend a whole day with him. He is a very jealous father. He isn’t gonna show you love, but anybody that gets closer to us than him he would tell them, ‘Leave my boys alone!’.”

“To tell you the truth, I never have felt close to him. He has always been like a mystery man.” (ANI)

Robot that mimics humans from the inside out

London, Sept 17 (ANI): Boffins have developed an amazing skeleton robot that moves just like humans.

The creation is known as an “anthropomimetic robot”.

Using human anatomy as a blueprint, scientists have replicated tendons using kite lines.

And used elastic bands to mimic the bounce of a muscles, reports The Sun.

The University of Sussex with help of institutions across Europe developed the stunning invention – called the Eccerobot.

Owen Holland, who is leading the Eccerobot project, said: “We want to develop these ideas into a new kind of anthropomimetic robot which can deal with and respond to the world in ways closer to the ways that humans do.”

The project team believe the Eccerobot – which could also be fitted with artificial intelligence – could be the most life-like humanoid so far. (ANI)

Katherine Heigl, Josh Kelley adopting baby girl

Washington, Sep 10 (ANI): Grey’s Anatomy star Katherine Heigl and her singer husband Josh Kelley are said to be ready to adopt a baby girl.

The pair, who had earlier not spoken about starting a family, has now decided to adopt a girl from Korea, the same way Heigl’s sister did.

“Katherine and Josh are adopting a baby,” Us magazine quoted the actress’ rep as telling People magazine.

Meanwhile Heigl, 30, who married Kelly, 29, in December 2007, recently hosted a baby shower for Ellen Pompeo. (ANI)

Some Aussie frogs raise pitch of love songs to counter traffic noise

Washington, Aug 26 (ANI): Some Aussie frogs often raise their pitch as they serenade their partners, in order to counter traffic sounds, according to a study.

Kirsten Parris, an ecologist at the University of Melbourne, says that one species of frog in Melbourne is changing the pitch of its love song to be heard above the roar of the road.

For the study, Parris visited many urban ponds and pools inhabited by frogs, measuring traffic noise, which is, unfortunately, at the same low frequencies as many frog mating calls.

But, for the onomatopoeic ‘pobblebonk’ (Limnodynastes dumerilii), she found that a call that could originally be heard by a female 800 metres away might only carry 98 metres above 60 decibels of traffic noise, an average value for Melbourne.

She has also discovered that the southern brown tree frog (Litoria ewingii) seems to be compensating for the traffic noise by increasing the pitch of its calls1 (listen to before and after calls).

Parris suggested that installing noise barriers at strategic points around a road could help urban frogs to hear each other.

She further said that creating habitats where they thrive – such as ponds with sloping rather than steep sides – would also make sense.

“Cities provide some of the last habitat for a range of frog species around the world. So if we only worry about conserving frogs and their habitats outside cities, some of these frogs may well go extinct,” she said.

She added: “Some frog species are very sensitive to environmental changes”, but “others are quite adaptable and can persist in urban habitats if we gave them a bit of help”.

However, Kris Kaiser, an ecology graduate student at the University of California, Los Angeles, has put forward a note of caution on the subject of these amphibians’ adaptability.

“Frogs, unlike birds, are thought to have the frequency of their calls somewhat constrained by their anatomy. There is often a relationship between body size and frequency of call,” he said.

Thus, he claimed that the creatures’ ability to compensate for traffic noise may be limited.

The study was presented at the International Congress of Ecology in Brisbane. (ANI)

MJ ‘wanted his kids to become doctors’

London, August 9 (ANI): Michael Jackson once aspired to become a medicine man and wanted his children to follow the same path, it has emerged.

A friend claimed that the King of Pop wanted to see his kids- Prince, 12, Paris, 11, Blanket, 7- study hard in order to follow the respected profession of being doctors and not enter the glamour world.

“Michael also got his children interested in it. He made sure they were constantly learning. He wanted them to be highly educated and to follow a noble and well-respected profession – becoming a doctor was ideal,” the Daily Star quoted the pal as saying.

The source said: “He didn’t want them to have the same troubles he had by going into showbiz. Paris was particularly interested in learning about anatomy.

It was apparently one of the reasons why he wanted Dr. Conrad Murray to stay with his family, who is now suspected of giving the singer powerful anaesthetic drugs which killed him.

The insider added: “That’s why Michael liked Dr Murray so much. He said the doctor always had time for the children and that he spoke to Prince and Paris about medicine and what it takes to be a doctor.

“In particular, Paris and Dr Murray spent quite a bit of time discussing his role as a cardiologist.”

In fact, the pop legend’s 11-year-old daughter totally trusted the personal physician, the source said: “At the hospital on the day Michael died, Paris still had a lot of faith in Dr Murray because of the chats they’d had.

“She asked her gran Katherine how her daddy could have died because Dr Murray was the ‘world’s best cardiologist’.”

The insider further revealed that Jackson was obsessed about becoming a medical practitioner and had even carried out a clandestine human dissection.

The pal added: “Michael secretly went along to dissect a foot, at the university, I think. I’m not sure when that was but he spoke about how interesting it was. He said it was his ultimate goal to become a doctor. I don’t think he quite realised how many years of study that takes.

“Michael ordered hundreds of books about medicine and the human body and avidly read them.

“He was a very intelligent, articulate and educated man who loved soaking up knowledge from books. He encouraged his children to do the same.” (ANI)

Why minor neuromuscular damage can affect one’s ability to complete everyday tasks

Washington, July 9 (ANI): In what may help understand why minor damage to the neuromuscular system can at times profoundly affect one’s ability to complete everyday tasks, scientists have found that activities combining movement and force tax the brain to capacity, countering a long-held belief that difficulty with dexterous tasks results from the limits of the muscles themselves.

“Our results show how much the mechanics of the body, and a given task, affect what the brain can or can’t do,” said Francisco Valero-Cuevas of the Brain-Body Dynamics Lab at the University of Southern California, who led the research.

“The so-called ‘problem’ of muscle redundancy-having too many muscles and joints to control-may not be the only challenge the brain faces when controlling our bodies. Rather, we seem to have about as many muscles as we need, and not too many, as others have proposed in the past.

“The scientific world and the clinical world have long been arriving at conflicting conclusions, and this work begins to resolve the paradox.

“While neuroscience and biomechanics studies have suggested that muscles and joints are, in theory, redundant and provide numerous alternative solutions to simple tasks, clinicians routinely see people seeking treatment for hand disability resulting from relatively minor conditions such as aging,” added Valero-Cuevas.

The study followed previous experiments that suggested the brain and complex musculature can barely keep up with requirements posed by our anatomy and the mechanics of even ordinary, real-world, finger tasks like rubbing a surface.

The conclusions begin to explain why even minor damage to the neuromuscular system seems to produce real deficits in manipulation.

The research focused on simultaneous force and motion-specifically from fingers either pushing or rubbing a surface-with volunteers conducting the experiment at defined, yet varying, speeds.

Knowing the force-producing properties of muscle, the researchers expected the rubbing motion would show reduced downward force as the speed of motion increased.

Surprisingly, whether rubbing slowly or at a pace 36-times faster, speed had little affect on the downward force the volunteers could produce.

The researchers interpret the results to mean the brain is sufficiently occupied by the physical demands of combining motions and forces, so the muscle properties are not the limiting factors for how much force the fingers can create.

“This begins to explain the clinical reality that when something in the system is damaged, either in the brain or body, we can see losses of function. We are not as ‘redundant’ as we thought,” said Valero-Cuevas.

The research team is conducting additional research to determine what exact neural and anatomical mechanisms are producing these results.

The current study has been published in the Journal of Neuroscience. (ANI)

Meet the man whose prostate cancer has been treated by a robot

London, July 1 (ANI): Taking a big leap in the fight against prostate cancer, doctors have for the first time treated a British patient using a surgical robot.

Jeremy Lineham, 48, of Chichester, West Sussex, has become the first patient in Europe to have his prostate removed with the 2 million pounds da Vinci Si gadget and check out of the hospital the next day.he keyhole surgery was carried out by a team of doctors at London’s Guy’s Hospital, where an earlier version of the robot has been used for five years.

“Jeremy’s operation was a great success and we were impressed with the enhanced ­performance of the new robot,” The Daily Express quoted consultant urologist Declan Murphy as saying.

“Its dexterity and range of motion is far greater than the human hand, so the surgery is much more precise.

“The 3D high-definition massively enhances our view of the anatomy and with dual consoles two surgeons could operate simultaneously.

“This will allow training in a way not previously possible.

“We are planning to update to this version in the next few months so our patients can benefit from the best technology available,” he added.

Lineham said: “It’s incredible. Less than 24 hours after major surgery I was on my way home, and I don’t have to take any further medication for the cancer because the whole gland has been removed.” (ANI)

Incisionless procedure ‘reverses weight gain after gastric bypass surgery’

Washington, June 30 (ANI): Scientists have offered an incisionless procedure to reverse weight gain after gastric bypass surgery.

To perform the procedure, known as ROSE (Restorative Obesity Surgery, Endolumenal), a small, flexible endoscope and tools are inserted through the mouth, down the esophagus, and into the stomach pouch during an outpatient procedure.

The tools, developed by USGI Medical Inc., are used to grasp, fold and stitch tissue to reduce both the diameter of the stomach opening and the volume of the stomach pouch. No cuts are made into the patient’s skin.

Santiago Horgan, MD, professor of surgery and director of the Center for the Treatment of Obesity at UC San Diego, looked at the six-month outcomes from a national registry of 116 patients who underwent the procedure.

The data showed that 88 percent of the patients stopped regaining weight after ROSE.

Overall, these 96 patients lost an average 18 percent of their excess weight six months after the procedure. For the purposes of the registry, excess body weight is defined as anything over a body mass index rating of 55.

One patient in the study lost 66 pounds or 84 percent of her excess weight during that six-month time period. Patients who were most successful losing weight after their original gastric bypass had the best results following the ROSE procedure.

This subset of patients dropped 29 percent of their excess weight during the six months after ROSE.

“We believe this registry represents the largest collection of data showing the effectiveness, safety and durability of the ROSE procedure,” said Horgan.

“There are not many options to repair a failing gastric bypass. Invasive procedures to restore the anatomy are complicated and risky for most patients. In comparison, there were no significant complications associated with ROSE and most of the patients lost clinically relevant amounts of weight,” Horgan added.

The data was presented at the annual meeting of the American Society of Metabolic and Bariatric Surgeons. (ANI)

Katherine Heigl to star in Warner Bros’ Life as We Know It

Washington, Jun 24 (ANI): ‘Grey’s Anatomy’ star Katherine Heigl is all set to star in Warner Bros’ romance movie “Life as We Know It”.

Greg Berlanti will direct the movie, and Barry Josephson and Paul Brooks will produce it, reports Variety.

The project dates back to 2001, and the story follows two unattached adults whose worlds are turned upside down when their mutual best friends die in an accident and name them as caregivers for their orphaned daughter.

The movie, which had also been at Fox before Warner Bros. took it up, will have Heigl and her mother Nancy Heigl exec producing it. (ANI)

Katherine Heigl to star in Warner Bros’ Life as We Know It

Washington, Jun 24 (ANI): ‘Grey’s Anatomy’ star Katherine Heigl is all set to star in Warner Bros’ romance movie “Life as We Know It”.

Greg Berlanti will direct the movie, and Barry Josephson and Paul Brooks will produce it, reports Variety.

The project dates back to 2001, and the story follows two unattached adults whose worlds are turned upside down when their mutual best friends die in an accident and name them as caregivers for their orphaned daughter.

The movie, which had also been at Fox before Warner Bros. took it up, will have Heigl and her mother Nancy Heigl exec producing it. (ANI)

Ten steps to extended massive orgasm

Washington, June 23 (ANI): While majority of couples wish to have extended massive orgasm (EMO), not everybody comes down to experiencing these repeated orgasmic waves.

Lovers experiencing one of these massive orgasms have reported enjoying more of life’s joys in general, becoming nicer and more generous in their relationship.

An EMO can last minutes or hours, offering up blissful sensations at increasing intensities, reports Fox News.

And here are the tricks of this tantalizing trade:

1. Truly recognize your pleasure

You want to immediately approve of your present sensations. This starts before you even get in the sack by overcoming anxieties you have about sex. This may require identifying limitations you’ve been taught about sex, like how you’re supposed to respond (or not respond). You need to then challenge any social conditioning that impedes upon your response.

Ridding yourself of the uninvited “others” in your bed will enable you to solely focus on the orgasmic sensations, including ones that come from simply anticipating action.

2. Learn to relax

Lovers have the tendency to tense up during sexual excitement, which is not conducive to extended orgasm. You need to be able to surrender your nervous system during genital stimulation. It’s this letting go of tension that allows you to embrace your pleasure.

3. Get in the know

The more we know about our bodies, sex, and sexual response, the better we can recognize sensations, the more we can lose ourselves in them. Become knowledgeable about sexual response, sexual anatomy, and erotic techniques.

4. Give yourselves time for pleasuring

Lovers may stimulate each other by fantasizing out loud, taking your time getting to the genitals and hot spots. Teasing allows for greater energy awareness and arousal, and these are what make the experience ultimately so mind-blowing.

5. Touch for pleasure

You can show your partner that you are into the moment by informing them about what you are going to do so he or she can surrender more easily. Highlighting a lover’s physical responses further enables them to tune into the sensations.

6. Learn to channel your energy

You want to get out of your head, directing your energy to your groin. This will make for more explosive results, plus help you to further tune into your sexual response.

7. Become an effective communicator

To amplify things up, you may need to request changes that will intensify your pleasure if you’re the receiver. As the giver, you may need to ask for feedback or direction. In either case, asking for more will help you to feel more. Giving approval can do wonders for a lover’s ego.

8. Develop your pelvic floor muscles

Exercising your pubbococcygeus (PC) muscle will put you more in tune with your sexual response. It’s also what makes for more powerful orgasms.

9. Have plenty of lubricant handy

As you will be loving for the long-haul, make sure you avoid the friction, pain, and discomfort that can result from working each other raw by using lube.

10. Do away with any drive-thru mentality

Having an EMO isn’t like going for fast food. One can’t go into it thinking instant gratification. Instead, approach it as though training for a sport. (ANI)

How the body differentiates between a scorch and a scratch

Washington, May 20 (ANI): American scientists have shed new light on how the body figures out whether it has been stuck by a pin or burnt by a match.

Researchers from the California Institute of Technology (Caltech) and the University of California, San Francisco (UCSF) have found that this sensory discrimination begins in the skin at the very earliest stages of neuronal information processing, with different populations of sensory neurons-called nociceptors-responding to different kinds of painful stimuli.

“Conventional wisdom was that the nociceptive neurons in the skin can’t tell the difference between heat and mechanical pain, like a pin prick. The idea was that the skin is a dumb sensor of anything unpleasant, and that higher brain areas disentangle one pain modality from another, to tell you if you’ve been scorched or scratched,” says David Anderson, Seymour Benzer Professor of Biology, a Howard Hughes Medical Institute (HHMI) Investigator, and one of the paper’s lead authors.

However, that was not sufficient to understand the control of pain-avoidance behavior, the researcher added.

“We were asking the cells what the cells can sense, not asking the animal what the cells can sense,” he said.

For their study, Anderson and his colleague Allan Basbaum, chair of the Department of Anatomy at UCSF, created a genetically engineered mouse in which specific populations of pain-sensing neurons could be selectively destroyed.

The researchers were then able to see if the mouse continued to respond to different types of stimuli by pulling its paw away, when exposed to a relatively gentle heat source or poked with a nylon fishing line.

When they killed off a certain population of nociceptor neurons, the mice stopped responding to being poked, but still responded to heat.

When the researchers injected a toxin to destroy a different population of neurons, the mice stopped responding to heat, but their sense of poke remained intact.

“This tells us that the fibers that mediate the response to being poked are neither necessary nor sufficient for a behavioral response to heat, and vice versa for the fibers that mediate the response to heat,” Anderson said. he researcher further said that neither of the two classes of sensory neurons seemed to be required for responding to a painful cold stimulus, like dry ice.

He said that research into pinpointing that population of cells was ongoing.

“This tells us that the discernment of different types of painful stimuli doesn’t happen only in the brain-it starts in the skin, which is therefore much smarter than we thought.

That’s a pretty heretical point of view,” said Anderson.

The study has been published in the early online edition of the Proceedings of the National Academy of Sciences (PNAS). (ANI)

47-mln-yr-old fossil “missing link” between humans and lemurs

Washington, May 20 (ANI): The analysis of a 47-million-year-old fossil, dubbed “Ida”, has led paleontologists to suggest that it is a critical “missing link” species in primate evolution, which connects humans and lemurs.

According to a report in National Geographic News, in a new book, documentary, and promotional Web site, paleontologist Jorn Hurum, who led the team that analyzed the 47-million-year-old fossil, suggests that the fossil bridges the evolutionary split between higher primates such as monkeys, apes, and humans and their more distant relatives such as lemurs.

“This is the first link to all humans,” said Hurum, of the Natural History Museum in Oslo, Norway. “Ida represents the closest thing we can get to a direct ancestor,” he added.

Ida, properly known as Darwinius masillae, has a unique anatomy.

The lemur-like skeleton features primate-like characteristics, including grasping hands, opposable thumbs, clawless digits with nails, and relatively short limbs.

“This specimen looks like a really early fossil monkey that belongs to the group that includes us,” said Brian Richmond, a biological anthropologist at George Washington University in Washington, D.C.

Richmond noted that there’s a big gap in the fossil record from this time period.

Researchers are unsure when and where the primate group that includes monkeys, apes, and humans split from the other group of primates that includes lemurs.

“Ida is one of the important branching points on the evolutionary tree, but it’s not the only branching point,” Richmond said.

At least one aspect of Ida is unquestionably unique: her incredible preservation, unheard of in specimens from the Eocene era, when early primates underwent a period of rapid evolution.

“From this time period there are very few fossils, and they tend to be an isolated tooth here or maybe a tailbone there,” Richmond explained.

“So you can’t say a whole lot of what that (type of fossil) represents in terms of evolutionary history or biology,” he added.

In Ida’s case, scientists were able to examine fossil evidence of fur and soft tissue and even picked through the remains of her last meal: fruits, seeds, and leaves.

What’s more, the newly described fossil was unearthed in Germany’s Messel Pit.

According to Richmond, Ida’s European origins are intriguing, because they could suggest-contrary to common assumptions-that the continent was an important area for primate evolution. (ANI)

3-D kidney atlas to help researchers, physicians treat renal diseases

Washington, May 16 (ANI): In a bid to diagnose and treat renal diseases early and more successfully, researchers from nine European countries have spent four-and-a half years to create a three-dimensional virtual “Kidney Atlas”, which incorporates the latest research findings on the development and diseases of the kidney.

The Kidney Atlas was part of the European Renal Genome Project (EuReGene), coordinated by the Max Delbruck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, which the European Union (EU) funded with more than 10 million euros.

Renal disease not only affects the elderly because of hypertension and diabetes, but also targets children, who are often born with congenital renal anomalies.

Particularly, the increase in the incidence of type 2 diabetes has caused a rise in the number of renal patients.

While the primary aim of the Kidney Atlas is to map genes that play a key role in renal diseases, it also contains other data, for example on anatomy.

The Kidney Atlas, primarily directed towards both basic researchers and clinicians, also contains information for the general public.

The Atlas is based upon various Genome Projects, and the scientists involved in its creation were pathologists, developmental and molecular biologists as well as geneticists from 14 research groups from non-university institutions, universities and six university clinics.

Project coordinator, Professor Thomas Willnow (MDC), has said that the Kidney Atlas will also be of great significance for the research of metabolic disorders, which lead to kidney damage such as diabetes.

The Kidney Atlas was presented at MDC during a two-day symposium, which was attended by approximately 100 researchers. (ANI)

Gene in breast cancer pathway identified

Washington, May 13 (ANI): In a new study, scientists at Albert Einstein College of Medicine of Yeshiva University have unravelled a mechanism responsible for turning on and off a gene crucial to breast cancer spread.

Einstein scientists had previously discovered a gene called ZBP1 (zipcode binding protein 1), which helps cells to move, grow and organize spatially.

“ZBP1 is very active in the developing embryo but largely silent in adult tissues,” said Dr Robert H. Singer, professor and co-chair of anatomy and structural biology and co-director of the Gruss-Lipper Biophotonics Center at Einstein.

This gene has been found active in several types of cancer, including breast, colorectal, and non-small cell lung cancers; but the gene is silenced in metastasizing cancer cells.

In the new study, Singer and another Einstein scientist, Dr John Condeelis sought to determine how ZBP1 gene is activated and silenced and how it influences the spread of breast cancer.

The find may offer potential drug targets for preventing metastasis.

After examining mouse, rat, and human breast cancer cells, they found that ZBP1 silencing occurs when a methyl group (CH3) attaches to ZBP1′s promoter region (the segment of a gene where gene expression is initiated).

The attachment of CH3 prevents the promoter from binding to a protein called beta-catenin. And without beta-catenin, the ZBP1 gene is effectively silenced.

The study showed that the silencing of ZBP1 increases cancer cells’ ability to migrate and promotes the proliferation of metastatic cells.

The researchers claim that the study has important implications for forecasting breast cancer outcomes.

They said that signs of ZBP1 silencing in breast cancer cells would indicate that a breast tumour is likely to spread information that would help in choosing a treatment strategy.

“If you could turn on this protein in cancer cells, or prevent it from being turned off, you could seriously reduce the ability of the cells to metastasize,” said Singer.

The study appears in the Journal of Cell Science. (ANI)

Meditation helps build stronger brains

Washington, May 13 (ANI): A new study has confirmed what many people believed: meditation helps increase gray matter.

A research team from University of California, Los Angeles scanned the brains of people who meditate and found that certain regions in the brains of long-term meditators were larger than in a similar control group.

Meditators showed significantly larger volumes of the hippocampus and areas within the orbito-frontal cortex, the thalamus and the inferior temporal gyrus – all known for regulating emotions.

“We know that people who consistently meditate have a singular ability to cultivate positive emotions, retain emotional stability and engage in mindful behaviour,” said Eileen Luders, lead author and a postdoctoral research fellow at the UCLA Laboratory of Neuro Imaging.

“The observed differences in brain anatomy might give us a clue why meditators have these exceptional abilities,” Luders added.

During the study, the research team looked at 44 people. Half were asked to practice various forms of meditation such as Zazen, Samatha and Vipassana and the other half acted as the control group.

More than half of all the meditators said that deep concentration was an essential part of their practice, and most meditated between 10 and 90 minutes every day.

The brains of the meditators showed larger volumes of the right hippocampus and increased gray matter in the right orbito-frontal cortex, the right thalamus and the left inferior temporal lobe.

Because these areas of the brain are closely linked to emotion, Luders said, “these might be the neuronal underpinnings that give meditators’ the outstanding ability to regulate their emotions and allow for well-adjusted responses to whatever life throws their way.”

The study is published in the journal NeuroImage. (ANI)

Sacha Baron Cohen’s painful encounter with bleaching process

London, May 8 (ANI): Comedian Sacha Baron Cohen was left in so much pain after a body bleaching process went insanely wrong that he could not sit for three days.

Baron decided to bleach his body to fit into his character of a gay Austrian fashion reporter in his forthcoming flick ‘Bruno’, as he was told that mostly gays are hairless. He thought that bleaching would make his hair invisible.

However, things took a turn for worse when the bleaching gave him a burning rash , which needed emergency treatment.

“Sacha is committed to as much realism as he can muster in his films. Gay. He’d heard that all-over hairlessness is a popular trend in the gay community, so he thought he’d bleach all his hair so it looked invisible,” The Sun quoted a source as saying.

“But it quickly turned into a disaster. Shortly after having the procedure done he felt a burning sensation and it grew steadily worse. He had a bad allergic reaction to hydrogen peroxide, which is a strong bleaching agent. It was so severe around a certain part of his anatomy that he couldn’t sit down for three days,” the source added.

Baron then met doctors and got rid of the rash within a few days.

However, his crew members could not help but laugh, as Baron could not even sit for three days due to which the shooting was delayed.

“He had to make an emergency appointment with the doctors, who gave him some medication to counter the irritation,” the source said.

“Crew members found the whole incident hilarious and it slowed down filming for a bit, but Sacha soon got over the discomfort. He has suffered no long-lasting ill effects,” the source added.

Bruno is due to hit cinemas on July 10. (ANI)