Men with asthma and eczema ‘at reduced cancer risk’

Washington, May 12 (ANI): Allergic conditions such as asthma and eczema that result from a hyper reactive immune system might enhance the body’s ability to remove malignant cells, which might in turn lower cancer risk, say researchers.

The researchers published their finding in Annals of Allergy, Asthma & Immunology, the scientific journal of the American College of Allergy, Asthma and Immunology (ACAAI).

“Allergic conditions such as asthma and eczema that result from a hyper reactive immune system might enhance the body’s ability to remove malignant cells, which might in turn lower cancer risk,” said Mariam El-Zein, PhD, INRS-Institut Armand-Frappier, Laval, Québec, Canada, lead author of the article. “In our study, men with asthma had lower odds of getting stomach cancer and those with eczema had lower odds of developing lung cancer, when compared to men who did not have these conditions.”

The population-based case-control study was conducted in Montreal, Québec over a seven-year period among 3,300 male cancer patients and a control group of 500. Odds ratios were calculated for the association between asthma or eczema and more than 20 cancer types combined, as well as for each of eight common cancer types (stomach, colon, rectum, lung, prostate, bladder, skin and lymph nodes).

“We cannot fully explain why allergic conditions can decrease cancer risk but this research is promising,” said allergist Jonathan Bernstein, MD, Fellow of the American College of Allergy, Asthma and Immunology. “We hope future studies continue to explore this connection and the role the immune system plays in reducing cancer risk.” (ANI)

Changes in humidity, temperature may trigger asthma among kids

Washington, September 15 (ANI): Changes in humidity and temperature may trigger asthma among kids, suggests a report.

Published in the journal Annals of Allergy, Asthma and Immunology, the report says that such weather changes have been found to result in a rise in Emergency Department (ED) visits for paediatric asthma exacerbations.

“We found a strong relationship between temperature and humidity fluctuations with pediatric asthma exacerbations, but not barometric pressure,” said Dr. Nana A. Mireku, an allergist at Dallas Allergy Immunology private practice in Dallas, formerly at Children’s Hospital of Michigan, Wayne State University School of Medicine, Detroit.

“To our knowledge, this is the first study that demonstrated these correlations after controlling for levels of airborne pollutants and common aeroallergens.

“Our study is also one of the few to examine the possibility that the weather one or two days before the asthma exacerbation may be as important as that on the day of admission, as the additional ED visits occur one to two days after the fluctuation,” she added.

The authors of the report write that patients experiencing an asthma attack often complain that weather fluctuations are a major trigger.

Dr. Mireku said: “the latest National Institutes of Health guidelines list ‘change in weather’ as a possible precipitating factor for asthma, but no previous studies have really examined this potential trigger in a rigorous fashion.”

According to the report, the retrospective 2-year study was performed at a large urban hospital of 25,401 children visiting the ED for an asthma exacerbation.

The researchers collected data on climactic factors, pollutants and aeroallergens on a daily basis.

They used time series analysis to evaluate the relationship of daily or between-day changes in climactic factors and asthma ED visits, controlling for seasonality, air pollution and aeroallergen exposure.

The effects of climactic factors were evaluated on the day of admission and up to five days before admission.

The researchers found that a 10 percent daily increase in humidity on a day or two before admission was associated with approximately one additional ED visit for asthma.

The authors write that between-day changes in humidity from two to three days prior to admission were also associated with more ED visits.

Daily changes in temperature on the day of or the day before admission increased ED visits, with a 10 degree F increase being association with 1.8 additional visits.

“Asthma is the most common chronic illness in childhood. Allergists have long known that weather conditions such as extremely dry, wet or windy weather can affect asthma symptoms. This study further defines the role of temperature and humidity on children’s asthma and confirms the importance of working with patients to identify the source of their symptoms and develop treatment plans that help prevent them,” said allergist Richard G. Gower, president of the American College of Allergy, Asthma and Immunology (ACAAI). (ANI)

Cutting kids’ exposure to several allergens may help prevent asthma

Washington, July 8 (ANI): A review of studies have suggested that reducing kids’ exposure to a variety of allergens, rather than targeting a single ‘trigger,’ might be a better way to avoid asthma.

While some kids are genetically predisposed to developing the disease, parents might still be able to prevent or delay the onset of symptoms by minimizing exposure to likely allergens.

Review author Tanja Maas said: “Breastfeeding and house dust mite reduction seemed to be the most important interventions,” used in the studies.The food interventions focused on hydrolyzed formula as opposed to regular formula. The use of hydrolyzed formula was not shown to have any preventive effect. Breastfeeding, however, seemed to be very effective.”

Reviewed studies focused on 3,271 high-risk children – those having at least one close relative with asthma.

Led by Maas, a researcher of immunological disease at Maastricht University Medical Center, in the Netherlands, the authors analyzed nine studies.

They classified three of the studies as multifaceted, taking more than one approach to asthma prevention. These studies covered both inhalant and dietary types of allergen reduction, while the remaining six studies looked at one type of allergen reduction alone.

Dietary restrictions started in pregnancy or from the child’s birth. In studies that included a dietary approach, mothers were encouraged to breastfeed or use special formula and to delay the introduction of solid foods into the child’s diet.

Environmental interventions included the reduction of dust mites, pet allergens and exposure to tobacco smoke in the child’s immediate environment.

The majority of allergic sensitization probably happens in early childhood or adolescence.

“We see most seasonal allergy sensitization occur by five years of age. Eighty percent of food allergies are present by two to three years of age,” said paediatric allergist Harvey Leo, M.D., an assistant research scientist at the Center for Managing Chronic Disease at the University of Michigan.

The review appears in the current issue of The Cochrane Library, a publication of The Cochrane Collaboration. (ANI)

Pills, ginger or a nap: Some useful remedies against sea sickness

Berlin – Typical indicators for sea sickness are a dry mouth, cold sweat, dizziness and nausea, sometimes followed by vomiting.

Medically speaking sea sickness is a variation of motion sickness or kinetosis. Though it does not always end up with the affected person “feeding the fishes”, it can however ruin a boat trip. But, with the right medicine and a few useful tips, it can be kept under control.

Kinetosis is caused when “The body experiences difficulty with different and contradictory stimuli,” according to Michael Knappich, a doctor at the Berlin Centre for Travel and Tropical Medicine.

The rocking motion experienced at sea causes a discrepancy between what the eye can see and what our body’s sensory organs are telling our brains.

In the process, the body produces more histamines. According to a new theory by Reinhard Jarisch, an allergist from Vienna, histamines cause the symptoms of sea sickness.

Almost everyone can be affected by sea sickness. However, the degree to which individuals feel sick can vary greatly. “There are people who are very susceptible and those who don’t have any problems at all,” says Knappich.

People also react differently to the degree at which a boat rocks. “Some people feel very sick with just a small amount of movement, while long, rolling movement will cause sea sickness in others,” says Andreas Koch, a doctor at the German navy’s medical institute in Kronshagen near Kiel.

However, on big ships, such movements no longer cause difficulties for passengers.

“The stabilisers built into modern cruise ships have helped make sea sickness easy to deal with,” says Karl Rabe, a doctor aboard the MS Europa.

There are a few things you can do to reduce the chance of feeling sea sick. “You should avoid alcohol and smoking at least a day before commencing your journey,” Knappich advises.

On the day you set sail you should have slept enough and eaten small portions of food. “The stomach should be neither totally empty nor totally full.”

It is also better to stay in midship than at the bow or stern because that is where the sea swell is less pronounced.

If you do feel unwell, the best thing to do is go to the upper deck, get some fresh air and fix your gaze at a point on the horizon. It’s more likely you will fell ill below deck. “That’s where you will be looking at a vertical wall while your sensory organs are telling you the boat is rocking,” says Koch.

Another good tip according to Koch is to, “lie down in your bunk as sleeping lowers your levels of histamines.”

If you already know you are susceptible to sea sickness or the sea will be rough, you should take some medication before beginning the voyage.

“Antihistamines like diphenhydramine or dimenhydrinate are good for dealing with mild to severe symptoms,” says Knappich.

For more severe symptoms, he recommends taking scopolamine or promethazine. If you have not taken anything, and you are hanging over the railing, then the best thing is to take a suppository with diphenhydramine or metoclopramid.

“In acute cases we administer those substances by injection,” says ship’s doctor Rabe.

All of the above can cause drowsiness. In mild cases of sea sickness, sufferers should try some alternative forms of medication.

Ginger is one of the oldest traditional remedies. It appears to help in mild cases although there is no scientific proof. Sometimes vitamin C can be useful. The German navy’s medical institute is checking to see just how effective it is.

As vitamin C is known to break down histamines, it could have the same properties as anti-histamines, but without the associated side effects, said Koch. (dpa)