Why alcohol affects people in very different ways

Washington, May 19 (ANI): Researchers have found the key that could explain why alcohol affects people in different ways—a receptor gene variant.

A genetic variant of a receptor in the brain”s reward circuitry could determine whether the neurotransmitter dopamine is released in the brain following alcohol intake, found researchers at the National Institute on Alcohol Abuse and Alcoholism (NIAAA).

Dopamine is involved in transmitting the euphoria and other positive subjective effects produced by alcohol.

The findings help explain the diverse genetic susceptibility for alcohol use disorders,

“By advancing our understanding of the neurobiology that underlies the addictive properties of alcohol, this finding helps us understand why alcohol affects people in very different ways. This kind of information also aids the development of personalized medications for alcohol problems,” said NIAAA Acting Director Dr. Kenneth R. Warren.

Receptors for brain molecules known as opioid peptides help initiate the neurochemical reactions that underlie the positive effects produced by alcohol.

Activation of the mu-subtype of opioid receptor following alcohol consumption triggers the release of dopamine from the forebrain.

“But there is much variation in alcohol-induced responses that are thought to be related to dopamine. Previous studies by our group and others suggest that variants of opioid genes may contribute to the observed variation, possibly through effects on alcohol-induced dopamine release,” explained Dr. Markus Heilig.

For example, he noted that people who carry the mu-opioid receptor variant designated as 118G report increased euphoria following alcohol consumption.

Heilig”s group has reported that a similar mu-opioid receptor variant in monkeys heightened the stimulating effects of alcohol and increased their alcohol consumption.

In the current study, first author Dr. Vijay A. Ramchandani and colleagues explored whether the 118G mu-opioid receptor variant influences dopamine release from a forebrain region called the ventral striatum in response to alcohol.

Using human positron emission tomography (PET), an imaging technique that allowed the researchers to analyze dopamine activity in the brain, they compared dopamine release in two groups of people that had been given a dose of alcohol.

The groups consisted of those who carried a copy of the gene for the 118G mu-opioid receptor variant, and those who carried only genes for the more common 118A variant.

They found that only people with the 118G variant had a dopamine response to alcohol – no such response happened in subjects with the 118A receptor variant.

“Taken together, our data strongly support a causal role of the 118G variant of the mu-opioid receptor to confer a more vigorous dopamine response to alcohol in the ventral striatum. The findings add further support to the notion that individuals who possess this receptor variant may experience enhanced pleasurable effects from alcohol that could increase their risk for developing alcohol abuse and dependence. It may also explain why these individuals, once addicted, benefit more from treatment with blockers of endogenous opioids,” said Ramchandani.

The study has appeared online in Molecular Psychiatry. (ANI)

Psychological problems during childhood create long-term economic losses

Washington, May 14 (ANI): Childhood psychological disorders could diminish people”s ability to work and earn as adults, according to a study.

People who suffer from childhood conditions such as depression and substance abuse are less likely to be married, attain less education and see their income reduced by about 20 percent over their lifetimes, according to findings published online by the journal Social Science & Medicine.

“This study shows childhood psychological disorders can cause significant long-lasting harm and can have far-reaching impact on individuals over their lifetimes,” said James P. Smith, the study”s lead author and corporate chair of economics at RAND, a nonprofit research organization. “Our findings illustrate what the enormous potential might be of identifying and treating these problems early in life.”

Researchers examined information from a large study that has followed American families for more than 40 years and found evidence that the impact of childhood psychological problems have lasting impact across many measures of economic success.

Researchers also found that people who reported childhood psychological problems were 11 percentage points less likely to marry than their siblings who did not suffer such problems.

Even when people in the group do marry, the income earned by their spouse is lower than seen among other couples.

People who reported psychological problems during childhood on average reported about half a year less of schooling than those who did not report problems. The schooling differences were greater among those who reported drug or alcohol problems.

“Not all of the people who have psychological problems during childhood will carry these problems into adulthood,” said Smith. “But they are 10 to 20 times more likely than others to have these shortfalls during adulthood. There clearly are large economic costs during adulthood caused by childhood psychological conditions.”

The results in the study are drawn from the Panel Study of Income Dynamics, the largest ongoing study of American families. (ANI)

Deadly soil bacteria kills 10 people in NT

A dangerous bacteria found in soil has claimed the lives of 10 people in the Northern Territory, the Centre for Disease Control says.

Melioidosis usually strikes during the northern Australian wet season, which runs from about November until April.

The centre’s acting director, Dr Peter Markey, says about 20 to 30 infections usually occur each wet season, resulting in between two and four deaths.

But Dr Markey says this wet season has seen the number of infections surge.

“This year we’ve had 72 cases so far,” he said.

“That is over three times [what we would normally expect] and well ahead of any other season that we’ve had.

“And 10 of those people have sadly passed away from the melioidosis.”

He says all of the people who have died have been aged over 30 and had pre-existing medical conditions, including diabetes, lung disease and alcohol problems.

Dr Markey says melioidosis infections had occurred in urban and rural areas of Darwin, in Arnhem Land, in Katherine and in Central Australia.

“The bacteria live in the soil in the tropics and people can become unwell either inhaling the bacteria if they come into close contact with it or acquiring the infection through the skin via a cut or a sore.”

He said people should wear gloves and shoes when in contact with muddy soil to lower the risk of infection.

Nobody scrutinised Humphrey Bogart: Hasselhoff says of his alcohol addiction

London, April 24 (ANI): David Hasselhoff is so tired of the attention being paid to his alcohol related problems that he said in the olden days getting drunk used to be “normal” in Hollywood.

Hasselhoff, 57, has endured a public battle with booze for years and has been taken to hospital on several occasions, including for alcohol poisoning in October 2007.

But he is so put off by the scrutiny he is getting that he said no one ever gave screen legend Humphrey Bogart any grief.

“Back then things were different,” the Sun quoted Hasselhoff, who is currently in Germany to promote his autobiography ‘Making Waves’, as telling Bunte magazine.

“Back then every star smoked and drank. Think of Richard Burton or Humphrey Bogart.

“But nobody scrutinised them. Every kind of consumption was normal,” he added. (ANI)

Smoking, not history of alcohol abuse, ”impairs mental function”

Washington, Mar 16 (ANI): A new study suggests that men and women with a history of alcohol abuse may not see long-term negative effects on their memory, but female smokers do.

In a study, which involved 287 men and women aged 31 to 60, researchers found that those with past alcohol-use disorders performed similarly on standard tests of cognitive function as those with no past drinking problems.

However, the findings were not as positive when it came to tobacco.

In general, women who had ever been addicted to smoking had lower scores on certain cognitive tests than their nonsmoking counterparts. The same pattern was not true of men, however, the researchers report in the March issue of the Journal of Studies on Alcohol and Drugs.

The reasons for the disparate findings on alcohol and smoking are not fully clear. Nor do they necessarily mean that serious alcohol problems would not affect long-term memory and other cognitive abilities; most study participants who had ever had drinking problems met the criteria for alcohol abuse rather than the more serious diagnosis of dependence.

Alcohol abuse was diagnosed when people reported one symptom of problem drinking — drinking and driving, for instance, or failing to meet work or school obligations as a result of drinking. Dependence, on the other hand, required people to have at least three symptoms — such as needing to drink more and more to achieve the same effects and experiencing physical withdrawal symptoms when they did not drink.

If more study participants had been alcohol dependent, the findings on cognition might have been different, says lead researcher Dr. Kristin Caspers, an assistant research scientist in the department of psychiatry at the University of Iowa in Iowa City.

But the bottom line, she says, is that people with a history of alcohol abuse appear not to be “doomed” to suffer cognitive effects when current levels of drinking are in the light to moderate range. (ANI)

Grand final loss still a win for Bombers

You hear it said that football is more than just sport – it’s a religion or a way of life.

Certainly in the Tiwi Islands, just north of Darwin, it is a force for social change and a flag bearer of community standards.

The islands have produced some of the biggest stars in the AFL but the Tiwi Islands’ own side, the Tiwi Bombers, has never won the Northern Territory’s football competition.

This season, for the first time, the mostly-Indigenous Tiwi Bombers made it through to the NTFL grand final.

On Saturday night in Darwin the Tiwi Bombers came out firing. Fans say half the population of the Tiwi Islands came over for the game.

Charlie King was calling the game for the ABC.

“Terrific, exhilarating footy. I absolutely love it. It is exciting,” he said.

The Tiwi Islands’ fast style of football has propelled players such as Essendon’s Michael Long and Dean Rioli onto the national stage.

But up until three years ago the Tiwi Islands did not have their own team in the Northern Territory competition.

Michael Long was in the crowd on Saturday night to watch what he called a historic game.

“Football has just come in leaps and bounds and what it does for the community, having so many of the young blokes playing here, they play an important role for the next generation,” he said.

But the fans were disappointed. The Bombers were beaten by the power of St Mary’s and lost by 10 points.

There were plenty of tears, both on and off the field.

For the Tiwi Islands, the Bombers are more than a football team.

Charlie King says they are seen as inspiration for a community that has suffered serious social issues.

“Suicide problems, drug problems, alcohol problems, family violence problems,” he said.

“So many problems that they have had to overcome and to take that scenario, that situation and say we are going to make a football team out of you that is going to be successful is a big, big ask.

“Football gave them something to actually cling to. They will walk away from the game thinking, ‘we lost the premiership but we dealt with a lot of those other problems as well’.”

The players have agreed to a strict code of conduct that has been put in place.

This season three members of the club found themselves suspended after they tried to smuggle alcohol onto the Tiwi Islands after games in Darwin.

The club’s chairman, Allan McGill, says football is a key element of influencing change.

“If we can harness all the energy and enthusiasm that goes with the football world to influence other behavioural changes, it has got to be a positive for the Tiwi people,” he said.

That enthusiasm for football saw a post-match exodus from Darwin as Tiwi Islanders returned home for the grand final of their local competition.

Kevin Sheedy, the coach of the AFL’s new greater western Sydney team, was there too – on the hunt for new talent.

“I just think it is probably one of the most exciting areas for talent,” he said.

“This is one of the most exciting AFL areas that we really haven’t got right even yet and I think within the next five or 10 years, I think there will be an enormous amount of development in and around the game up here.”

Young age at first drink can turn under-15s into alcoholics

Washington, Sept 19 (ANI): Drinking at young age may affect genes linked to alcoholism and make youngsters vulnerable to severe problems, says a new study.

The study led by Dr Arpana Agrawal, from Washington University School of Medicine in St. Louis, revealed that the younger an individual was at first drink, the greater the risk for alcohol dependence and the more prominent the role played by genetic factors.

“There seemed to be a greater genetic influence in those who took their first full drink at a younger age,” said Agrawal.

“That’s very consistent with what has been predicted in the literature and in the classification of types of alcohol dependence, but we present a unique test of the hypothesis,” she added.

During the study, the researchers studied 6,257 adult twins from Australia and measured the extent to which age at first drink changed the role of heritable influences on symptoms of alcohol dependence.

The study showed that when twins started drinking early, genetic factors contributed greatly to risk for alcohol dependence, at rates as high as 90 percent in the youngest drinkers.

The team also found that those who were 15 or younger when they started drinking tended to have a greater genetic risk for alcohol dependence.

However, some who were 16 or older before they took their first drink later became alcohol dependent, but their dependence was related more to environmental factors.

“Something about starting to drink at an early age puts young people at risk for later problems associated with drinking,” Agrawal says.

“We continue to investigate the mechanisms, but encouraging youth to delay their drinking debut may help.

“Some early-onset drinkers do not develop alcohol problems and some late-onset drinkers do – we are working on why that is the case, but it is important to note that this is one risk factor among many and does not determine whether a person will, or will not, develop alcohol dependence.

“But age at first drink is a well-known risk factor, and there have been two main hypotheses about why:

One has been that common genetic and environmental factors contribute both to the risk for alcohol dependence and to the likelihood a person will be younger when consuming their first drink,” she added.

The study will be published Alcoholism: Clinical and Experimental Research. (ANI)

New prevention system may cut teen binge drinking 37pct

Washington, September 8 (ANI): A prevention system designed to reduce drug use and delinquent behaviour has been found to reduce rates of binge drinking among eighth-grade students in the U.S. by 37 per cent, when compared to teens who did not use the system.

In their study paper, researchers at the University of Washington write that eighth graders in the towns that offered the Communities That Care prevention system also had significantly lower levels of alcohol and smokeless tobacco use and engaged in fewer delinquent behaviours.

Published in the Archives of Pediatrics and Adolescent Medicine, the findings come from the ongoing Community Youth Development Study that compares teenagers living in 12 pairs of small- to moderate-size towns in Colorado, Illinois, Kansas, Maine, Oregon, Utah and Washington.

It is tracking the behaviour of more than 4,400 students for five years.

“This study shows we can prevent adolescent risk behaviors community wide by using this system,” said J. David Hawkins, who has developed the Communities That Care prevention system in collaboration with Richard Catalano, of the UW’s Social Development Research Group.

“The most dramatic finding concerned binge drinking. We asked youngsters if they had consumed five or more drinks of alcohol in one sitting in the past two weeks.

We know kids who drink that way are at risk for developing alcohol abuse and dependence later. This binge drinking is occurring when children are 13 and 14 years of age, so we are actually preventing the likelihood of later alcohol problems. This is very important from a public health standpoint,” added the lead author of the paper and founding director of the research group.

During the study, the researchers observed that 5.7 percent of the eighth-grade students in the intervention towns engaged in binge drinking in the past two weeks as compared to 9 percent of the eighth graders in the communities not using the system.

The team have revealed that their findings are based on data collected four years after each of the intervention towns began using the system.

The participants were also asked about their use of seven types of drugs – cigarettes, smokeless tobacco, inhalants, marijuana, alcohol, prescription drugs and other illicit drugs – during the past month.

The researchers say that teens in the intervention towns reported lower levels of use of all seven substances, and that the differences were statistically significant for alcohol and smokeless tobacco.

According to them, there was a 48 percent reduction in the use of smokeless tobacco and a 23 percent reduction in the number of teens drinking alcohol.

Data also showed a significant difference in the number of delinquent behaviours the students engaged in over the past year.

The study also found that young people in the communities using the prevention system were significantly less likely to begin smoking tobacco, drinking alcohol or committing delinquent acts between the fifth and eighth grades.

“What makes this system different from other prevention efforts is that it provides community coalitions with scientifically based tools with which to make decisions based on what is important to each town,” said Hawkins.

“The key is empowering each community to make scientifically grounded decisions about what program they need. That builds ownership.

“Communities That Care provides a menu of tested policies and programs and offers a system for reassessment every two years so a community can change or modify its program to achieve the outcomes it wants,” Hawkins added. (ANI)

A person’s response to alcohol may help predict alcoholism risk

Washington, May 23 (ANI): A person who has a low level of response (LR) to alcohol is at a greater risk of developing alcohol-use disorders (AUDs), finds a new study.

The research team from University of California, San Diego has found that LR is a unique risk factor for AUDs across adulthood and is not simply a reflection of a broader range of risk factors.

“If a person needs more alcohol to get a certain effect, that person tends to drink more each time they imbibe,” said Marc A. Schuckit, director of the Alcohol Research Center, Veterans Affairs San Diego Healthcare System and corresponding author for the study.

“Other studies we have published have shown that these individuals also choose heavy drinking peers, which helps them believe that what they drink and what they expect to happen in a drinking evening are ‘normal’.

“This low LR, which is perhaps a low sensitivity to alcohol, is genetically influenced,” he added.

The study involving 297 men between 18 to 25 years showed that a low LR to alcohol predicted AUD occurrence over the course of adulthood even after controlling for the effects of other robust risk factors.

In short, LR is a unique risk factor for AUDs across adulthood, and not simply a reflection of a broader range of risk factors.

“A low LR at age 20 was not just a reflection of being a heavier drinker at age 20 when we tested these men, and it wasn’t an artifact of an earlier onset of drinking,” said Schuckit.

“We showed that a low LR at 20 predicts later heavy drinking and alcoholism even if you control for all these other predictors of alcohol problems at age 20,” he added.

The study appears in Alcoholism: Clinical and Experimental Research. (ANI)

David Hasselhoff’s ex-wife asking for spousal support after death

Washington, May 12 (ANI): David Hasselhoff’s ex-wife Pamela Bach has demanded a court order to guarantee that she continues to receive spousal support payments from the actor in case of his death.

The former couple had ended their 16-year marriage in 2006, and subsequently endured a lengthy divorce trial.

A year following the divorce, Hasselhoff’s health was publicly questioned when his alcohol problems were exposed after home video footage of the actor in a drunken state leaked onto the Internet.

Later, Bach made public pleas for the actor’s health, and admitted that she was worried that he could drink himself to death.

Then, the 56-year-old star checked into a rehabilitation facility in a bid to kick his drink demons.

And now, TMZ.com has reported that Bach has taken action on her concern, and has asked a California judge to order Hasselhoff to maintain his current life insurance policy, which would pay her spousal support from beyond his grave. (ANI)

Footballers ‘are seedier than criminals’

Melbourne, May 9 (ANI): Football stars are more likely to have alcohol problems, be more verbally aggressive and more sexually promiscuous than criminals, a new study has shown.

The study, which was published in the Australian Psychological Society’s journal InPsych, based its findings on responses of 50 AFL footballers.

In the research, volunteers were subjected to personality tests and their results were compared to the results of similar tests conducted on 940 convicted criminals, The Courier Mail reports.

According to News.com.au, the study found footballers scored significantly higher than both the social average and the offenders in measures of alcohol problems, anxiety, verbal aggression, sexual promiscuity and anti-social behaviour.

“The data suggested that AFL footballers were most likely to offend in the context of alcohol usage, through offences such as drunk and disorderly, drink driving, or violent or reckless behaviour,” the study authors reported.

“The relatively high sexual promiscuity scores suggested AFL footballers may potentially place themselves at greater risk for sex-related offences and vulnerability to scandal,” it added.

Professor Bob Montgomery, president of the Australia Psychological Society, said: “Very often to become a high profile person, you’re a risk taker. You’re willing to take a chance that other people might turn their back on.”

He said the group mentality of young men in football teams was also part of the problem. (ANI)

David Hasselhoff hospitalised for alcohol poisoning

Washington, May 4 (ANI): Former Baywatch star David Hasselhoff has been rushed to an L.A. hospital because of alcohol poisoning on May 2.

According to RadarOnline.com, the vodka-guzzling ‘America’s Got Talent’ judge was taken to Cedars-Sinai medical centre after his daughter Hayley, 16, found him unconscious on the floor of his home in Encino, California.

Hayley then called her mom and Hasselhoff’s estranged actress Pamela Bach, who lives 10 minutes away in Hollywood, and the duo then drove him to the hospital.

The 56-year-old actor, who has had a history of alcohol problems, was registered with a .39 alcohol level this time round.

While a source had earlier revealed that Hasselhoff was “barely breathing when they got him to the hospital,” reports suggest that he is recovering.

“This is about the seventh time he’s been taken to a hospital over the last few years with alcohol poisoning,” Us magazine quoted the source as saying.

According to TMZ, Hasselhoff’s rep, Judy Katz, said the star was “fine and well and happy and is celebrating his father Joe Hasselhoff’s 80th birthday tonight at dinner … along with his girlfriend, Kimberly.” (ANI)

Inter Milan cancel Adriano’s contract

Milan – Inter Milan Friday rescinded the contract of Adriano after the Brazil striker recently failed to return from international duty.

Inter said Adriano’s contract with the Serie A team had been ended with effect from April 1.

“Inter’s appreciation goes to Adriano for the eight years and 74 goals we lived through together,” the club said on its website.

After the last international break, Adriano, 27, failed to board a scheduled flight for Italy on April 3 and did not communicate his decision to his agent and Inter.

He then announced from Brazil that he was taking a break from football and cut off contact with coaches and teammates for three days.

Adriano is said to have suffered from alcohol problems and depression over the past two years, during which Inter allowed him periods of rest in Brazil. (dpa)

Scary anti-drinking ads don’t work, says leading expert

Melbourne, Apr 28 (ANI): Advertising campaigns designed to tackle problems such as alcohol among youngsters fail to work, says a prominent communications expert.

Noel Turnbull, adjunct professor in the School of Applied Communications at RMIT University, who is now a director of DrinkWise Australia, said that young people “think they’re immortal”.

“They simply don’t believe the risks are as great as other people say,” News.com.au quoted him as saying.

Pushing for a longer-term approach to tackling alcohol abuse, Turnbull has warned against approaches that “generate widespread community hostility and seek to control the bulk of moderate consumers of alcohol as if they were people with significant alcohol problems”.

While ridiculing on draft guidelines the National Health and Medical Research Council issued last year, he said that the Australian politicians might have been misled by their own campaign advertisements.

He said: “One of the reasons why governments like fear is that is the sort of advertising they do in a political context.

“They’ve demonstrated that negative advertising works when it comes to elections and assume that it also works when it comes to other forms of behavioural change, but the evidence for that is not quite so strong.”

On the other hand, Turnbull insisted that using social marketing to change behaviour would be a better approach.

He said: “We’re not going to solve social problems purely and simply by regulating them out of existence. We have to actually build social capital.

“It’s no good telling people this is the wrong thing to do. Long-term solutions are about building social capital and people’s own capacity to change.”

Turnbull will present his ideas at the forum of DrinkWise- an education body funded by the federal Government and the liquor industry. (ANI)

Strong bond with parents may keep teens away from alcohol problems

Washington, Apr 24 (ANI): Adolescents who share a strong bond with their parents often start drinking at a later age, which could subsequently prevent them from developing future alcohol problems, concludes a new study.

The results of the study highlight the importance of the role played by parents in the risk of problem drinking.

Earlier studies have indicated that the age at which kids start drinking governs whether they eventually develop alcohol-related problems, like getting into fights or having academic or work problems.

Thus, Dr. Emmanuel Kuntsche, of the Swiss Institute for the Prevention of Alcohol and Drug Problems in Lausanne, Switzerland, has said that it is often assumed that drinking at an early age, in and of itself, is the problem.

“Our work shows that the ‘preventive effect’ of a later drinking age is likely to be a side effect of a good parent-child relationship. In other words, the circumstances in which that first drinks occurs-and how parents deal with it-is important,” said Kuntsche.

In the study, researchers surveyed 364 teenagers three times over two years.

It was found that generally, teens, who reported an earlier drinking age during the first survey, tended to be drinking more heavily by the second survey and were at greater risk of drinking-related problems by the third survey.

After looking a little closer at the data, researchers noticed that only teenagers, who reported both a later drinking age and a high-quality relationship with their parents, had a lower risk of drinking problems compared with their peers.
high-quality relationship was one where teenagers felt they could discuss their problems with their parents and that their parents respected their feelings.

The findings, according to the researchers, suggest that such parent-child relationships can “trigger a spiral of healthy development during adolescence” that may lead to a lower risk of alcohol problems.

Kuntsche said that parents should remember how important they are when it comes to their children’s risk of substance abuse.

Also, being attentive to their children’s needs in general, may be one way to protect them from developing drinking problems.

The study is published in the May issue of the Journal of Studies on Alcohol and Drugs. (ANI)

Urban’s alcohol problems took our marriage for a toss: Kidman

Sydney, Apr 19 (ANI): Hollywood actress Nicole Kidman has admitted that her husband Keith Urban’s alcohol problems sent their fledgling union into a tailspin.

“We were thrown into his alcohol problems three months into the marriage and that was big,” The Sydney Morning Herald quoted the 41-year-old actress, as telling the Daily Mail newspaper.

The Australian beauty confessed that Urban had admitted his problem and spent time in rehabilitation, a step that made their relationship stronger.

“We became the closest we could become because we had to bare our souls. We did 10 years of marriage in just three months. When the addiction takes control of someone’s life, it’s terrifying. But there is hope, and we work on it every day,” she said.

Kidman said that giving birth to Sunday Rose in her 40s has given her a greater sense of her own mortality.

“It’s bittersweet,” she said.

“I want to be around to see Sunday Rose’s 21st birthday . . . My relationship with death used to be far more ambivalent . . . now it feels much more important for me to stay in the world,” she added. (ANI)

Adriano willing to keep playing, according to agent

Rome – The agent of troubled footballer Adriano has said that the striker has no intention of quitting playing despite his refusal to rejoin Inter Milan, Italian media reported. Gilmar Rinaldi arrived Tuesday in Milan to discuss Adriano’s futuer with the Italian champions as he remained in Brazil after being in the national squad for two 2010 World Cup qualifiers at the end of March.

“I think he will resume playing,” Rinaldi said. “He needs time to reflect and take a decision. He is quiet in Rio (de Janeiro) with his family. Now we wait to talk with Inter.”

Adriano, 27, failed to board a scheduled flight for Italy on April 3 and did not communicate his decision to his agent and Inter.

His absence triggered rumours that he had been arrested for being in a party with some wanted criminals and even that he had been killed.

Rinaldi, who last week dismissed all rumours, said the matter should be addressed with calm and serenity and denied that Adriano received offers from other clubs.

“There is a team, Inter, who hold a contract (until June 2010) and who six years ago brought Adriano to Italy (from Flamengo) and for whom there has to be some respect,” the agent said.

“I have to talk with them, explain everything and then evaluate the matter.”

Adriano is said to have suffered from alcohol problems and depression over the past two years, during which Inter allowed him periods of rest in Brazil.(dpa)

Adriano delays return to Inter Milan

Rome – Inter Milan on Sunday were awaiting the return of striker driano, who has remained in Brazil after being in the squad for two 2010 World Cup qualifiers over the past week.

La Gazzetta dello Sport reported that Adriano, 26, could return to Italy Monday or Tuesday. He failed to board a scheduled flight for Italy on Friday and did not communicate his decision to his agent and Inter.

Adriano has suffered from alcohol problems and depression over the past two years. Brazil coach Dunga kept him on the bench in games played against Ecuador on March 28 and Peru on Wednesday, but Inter coach Jose Mourinho didn’t want to dwell on his personal problems.

“I think we shouldn’t talk too much about this,” Inter coach Jose Mourinho said. “Everyone has understood that it’s not an easy situation … The only thing to do, on my side, with sadness and without bitterness or criticism, is saying nothing.

“We’ll see how all this will end for him. In this moment I think more about the person than about the footballer.

Jade Goody turns out to be ‘Slumdog saviour’

London, Mar 10 (ANI): The mysterious benefactor, who donated food, clothes and medicine at a children’s shelter in India, and helped 126 kids escape begging gangs, has been revealed to be Brit celebrity Jade Goody.

Goody, 27, had made the donation during a visit to a Delhi project run by British charity Railway Children though she was unable to reveal it at that time as her agreement with the charity had not then been finalised.

In her autobiography, Catch A Falling Star, she told how she donated 100,000 pounds to charities in the country, a large chunk of which went to these kids.

Bobby Mishra, a little five-year-old boy, who no longer has a father and whose mother suffers from alcohol problems, was grateful for the help Goody gave.

“Thank you so much for our lovely food and clothes, Jade,” the Sun quoted him as having said through a translator.

“You have helped us so much and made us very happy. We will all pray for you every day,” he said.

Goody had spent time with the children while she was at the centre, and Mrinalini Rao, 34, director of the Railway Children in India, who was present during the visit, was surprised at how easily she got on with the kids.

“I was amazed to see how Jade connected with the children,” she said.

“There were several moments when she had tears in her eyes while listening to their stories.

“The children were quite amazed at the ease and honesty with which she spoke about her life,” she stated.

Jade’s cash went to the Railway Children charity, which then passed it to Jeevodaya Society in Itarsi, whose shelter was built by UK charity Butterfield’s Edward Johnson Trust. (ANI)

Alcohol abuse ‘leads to depression, rather than vice-versa’

Washington, Mar 3 (ANI): A new research has challenged a popular belief after claiming that alcohol abuse leads to depression, and not the other way round.

Using data gathered from a 25-year study of health and development in New Zealand, David M. Fergusson, Ph.D., and colleagues at the Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand, examined the associations between alcohol abuse and depression.

A sample of 1,055 participants born in 1977 were assessed for both conditions at ages 17 to 18, 20 to 21 and 24 to 25 years and also asked questions about lifestyle and demographic factors.

At ages 17 to 18, 19.4 percent of the participants met criteria for alcohol problems and 18.2 percent for major depression; at ages 20 to 21, 22.4 percent had alcohol disorders and 18.2 percent major depression; and at age 24 to 25, 13.6 percent met alcohol disorder criteria and 13.8 percent had major depression.

At all ages, alcohol abuse or dependence was associated with an increased risk of major depression-those who fulfilled criteria for alcohol abuse or dependence were 1.9 times more likely to also fulfill criteria for major depression.

Three models were tested to fit the data-one in which major depression and alcohol abuse disorders had a reciprocal association within time, a second in which alcohol disorders caused major depression and a third in which major depression caused alcohol disorders.

“This analysis suggested that the best-fitting model was one in which there was a unidirectional association from alcohol abuse or dependence to major depression but no reverse effect from major depression to alcohol abuse or dependence,” the authors said.

“The underlying mechanisms that give rise to such an association are unclear; however, it has been proposed that this link may arise from genetic processes in which the use of alcohol acts to trigger genetic markers that increase the risk of major depression.

“In addition, further research suggests that alcohol’s depressant characteristics may lead to periods of depressed affect among those with alcohol abuse or dependence,” they added.

The causal links also may include an increased risk of depression due to stressful life circumstances brought by alcohol problems, including social, financial and legal issues.

“However, further research is required to elucidate the nature of the possible links between alcohol use and major depression,” the authors said.

The study has been published in the March issue of Archives of General Psychiatry, one of the JAMA/Archives journals. (ANI)