Why alcohol affects people in very different ways

Washington, May 19 (ANI): Researchers have found the key that could explain why alcohol affects people in different ways—a receptor gene variant.

A genetic variant of a receptor in the brain”s reward circuitry could determine whether the neurotransmitter dopamine is released in the brain following alcohol intake, found researchers at the National Institute on Alcohol Abuse and Alcoholism (NIAAA).

Dopamine is involved in transmitting the euphoria and other positive subjective effects produced by alcohol.

The findings help explain the diverse genetic susceptibility for alcohol use disorders,

“By advancing our understanding of the neurobiology that underlies the addictive properties of alcohol, this finding helps us understand why alcohol affects people in very different ways. This kind of information also aids the development of personalized medications for alcohol problems,” said NIAAA Acting Director Dr. Kenneth R. Warren.

Receptors for brain molecules known as opioid peptides help initiate the neurochemical reactions that underlie the positive effects produced by alcohol.

Activation of the mu-subtype of opioid receptor following alcohol consumption triggers the release of dopamine from the forebrain.

“But there is much variation in alcohol-induced responses that are thought to be related to dopamine. Previous studies by our group and others suggest that variants of opioid genes may contribute to the observed variation, possibly through effects on alcohol-induced dopamine release,” explained Dr. Markus Heilig.

For example, he noted that people who carry the mu-opioid receptor variant designated as 118G report increased euphoria following alcohol consumption.

Heilig”s group has reported that a similar mu-opioid receptor variant in monkeys heightened the stimulating effects of alcohol and increased their alcohol consumption.

In the current study, first author Dr. Vijay A. Ramchandani and colleagues explored whether the 118G mu-opioid receptor variant influences dopamine release from a forebrain region called the ventral striatum in response to alcohol.

Using human positron emission tomography (PET), an imaging technique that allowed the researchers to analyze dopamine activity in the brain, they compared dopamine release in two groups of people that had been given a dose of alcohol.

The groups consisted of those who carried a copy of the gene for the 118G mu-opioid receptor variant, and those who carried only genes for the more common 118A variant.

They found that only people with the 118G variant had a dopamine response to alcohol – no such response happened in subjects with the 118A receptor variant.

“Taken together, our data strongly support a causal role of the 118G variant of the mu-opioid receptor to confer a more vigorous dopamine response to alcohol in the ventral striatum. The findings add further support to the notion that individuals who possess this receptor variant may experience enhanced pleasurable effects from alcohol that could increase their risk for developing alcohol abuse and dependence. It may also explain why these individuals, once addicted, benefit more from treatment with blockers of endogenous opioids,” said Ramchandani.

The study has appeared online in Molecular Psychiatry. (ANI)

Having strong ties with friends and family helps people live longer

London, May 15 (ANI): Having a close-knit group of family and friends has more bearing on a person�s lifespan than genetics, a study has revealed.

The study involved the participation of 188 centenarians, several common factors emerged amongst this select group as most saw themselves as sociable, open-minded and optimistic. They also had very strong family-ties.

Researcher Robyn Richmond said genetics accounts for just 20 to 30 per cent of a person”s chances of living to 100, meaning personality and lifestyle have a major impact, the Daily Mail reports.

”Social contact with family and friends is very important,” she said. ”Centenarians have built up strong solid relationships, seeing family, friends and neighbours regularly.

”If they don”t have children, if they have very strong connections with their friends or if they are living in a nursing home that gets them doing interesting things with others who live there, they are more likely to live to 100.”

These folks have witnessed some major upheavals in their lives and are thus more open-minded, amenable to change and less hostile. Such a positive frame of mind is another feature of those who cross the coveted 100-year mark.

As far as lifestyle and habits are concerned, most of the centenarians did not smoke (barring two), and most consumed alcohol in moderation.

”Half have a drink each day but none a risky level of alcohol consumption,� says Professor Richmond, of New South Wales University in Sydney, which led the survey.

”It means even if you have got bad genes but you live a healthy life and stay positive, you could still have a very long life,” he adds summing it up. (ANI)

Coffee, soft drinks not tied to colon cancer risk

Washington, May 8 (ANI): Drinking large amounts of coffee and sugar-sweetened, carbonated soft drinks does not increase the risk of colon cancer, according to a new study.

The study has been published online May 7 in the Journal of the National Cancer Institute.

Some previous studies have suggested that coffee and tea may lower the risk of cancer, but others show that they could increase the risk. Tea, for instance contains anti-oxidants that in theory help prevent cancer but also has polyamines, which in theory promote cancer. Sugar-sweetened soft drinks are associated with weight gain, obesity, and other conditions that are potential risk factors for colon cancer.

For this study, Xuehong Zhang, M.D., Sc.D., and colleagues at the Harvard School of Public Health analyzed data from 13 studies conducted in North America and Europe. Among 731,441 participants in these studies, there were 5,604 who developed colon cancer. Those who drank large amounts of coffee—more than six 8-oz cups a day—were no more likely to develop the disease than those who drank less.

Likewise, those who drank more than 18 oz daily of sugar-sweetened, carbonated beverages had no higher risk of colon cancer. But the authors note that the results for sugar-sweetened carbonated beverages should be interpreted with caution because only 2 percent of the study population drank more than 18 oz of these beverages daily.

The results were similar regardless of sex, smoking status, alcohol consumption, body mass index, level of physical activity, and location of the tumor.

The authors found a modest association between drinking high amounts of non-herbal tea—more than four 8-oz cups a day—and colon cancer risk. However, they note that very few people in the study drank that much tea and that the association could be due to chance.

“Drinking coffee or sugar-sweetened carbonated soft drinks was not associated with colon cancer risk,” the researchers conclude. “However, a modest positive association with higher tea consumption is possible and requires further study.” (ANI)

Booze during pregnancy could lead to acute myeloid leukemia in kids

Washington, May 6 (ANI): Drinking alcohol during pregnancy could increase the risk of acute myeloid leukemia (AML) in children, according to a recent paper.

The study has been published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

Julie Ross, Ph.D., director of the division of pediatric epidemiology and clinical research at the University of Minnesota, said there are about 700 cases of AML in the United States in children each year.

“It”s quite rare, so we want to be careful about worrying parents too much,” said Ross, who was not involved in the study, but is an editorial board member of Cancer Epidemiology, Biomarkers & Prevention.

Ross and the lead researcher of this study, Paule Latino-Martel, Ph.D., research director at the Research Center for Human Nutrition in France, agreed that these findings should strengthen the public health recommendation against alcohol consumption during pregnancy.

“Despite the current recommendation that pregnant women should not drink alcohol during pregnancy, alcohol consumption during pregnancy is 12 percent in the United States, 30 percent in Sweden, 52 percent in France, 59 percent in Australia and 60 percent in Russia,” said Latino-Martel.

Latino-Martel and colleagues analyzed 21 case control studies. Alcohol intake during pregnancy, defined as a response to a yes or no question, was associated with a 56 percent increased risk of AML in children. The risk of AML was higher in children aged 0 to 4 years old at diagnosis. There was no significant association with acute lymphoblastic leukemia. (ANI)

Tax proposals good for health, environment

Experts believe proposed reforms to the Australian tax system will be good for preventative health and the environment.

The Henry tax review, released yesterday, proposes disincentives for smoking, alcohol consumption and the use of private transport, in line with recommendations from the Federal Government’s Preventative Health Task Force.

Public Health Association of Australia president Mike Daube, who was also on the task force, was optimistic about the review.

“Overall it is enormously encouraging to see the tax review being so consistent with the health recommendations,” Professor Daube said.

He says raising the cost of cigarettes and alcohol are the single most important means of reducing consumption.

“It’s a very big step forward,” said Professor Daube, who describes the present alcohol tax system as a “dog’s breakfast”.

However the Government says it does not plan to introduce a volumetric tax on alcohol at this stage.

The proposed tax would make drinks containing more alcohol more expensive.

“At the moment we’re seeing cask wine being advertised at $2 a litre,” Professor Daube said.

“That means that we’ve got cask wine cheaper than some soft drinks and even cheaper than some bottled water.”

National Alliance for Action on Alcohol spokesman Todd Harper also wants the volumetric tax.

“It’s been shown a 10 per cent increase in the price of alcohol leads to approximately a 5 per cent reduction in consumption,” he said.

“It has an extremely powerful impact.”

Mr Harper says a 2009 survey by VicHealth, of which he is also chief executive, shows two-thirds of the community support taxing drinks based on their alcohol content.

“There is not only economic support and public health support, but also community support for that reform,” he said.

Matter of time

But while Professor Daube and Mr Harper are disappointed the tax has not been adopted by the Government, they believe it is just a matter of time before it is introduced.

“I believe it will be introduced in the next few years,” Professor Daube said.

He says while there have been recommendations for a tobacco tax for a long time, this is the first time Treasury has provided such a clear recommendation on alcohol tax.

Just days before the release of the review, the Government announced a new anti-smoking policy which included a 25 per cent increase in tobacco excise.

Funds raised are to go toward supporting the Government’s proposed revamp of the health system.

The Government says it will also introduce plain packaging for cigarettes by 2012, introduce a ban on internet advertising of cigarettes and fund a large public education campaign.

“On tobacco you’d have to say Australia is now simply the world’s leading country,” said Professor Daube, who is also director of Curtin University’s Public Health Advocacy Institute and president of the Australian Council on Smoking and Health.

“I think other countries are going to follow suit. I think it’s just a real landmark.”

Road tax

The tax review also recommends a road user tax, which experts say will also have impacts on public health and the environment.

Urban public health expert Dr Chloe Mason, from UTS Institute for Sustainable Futures, says the proposal to make it more expensive to drive during peak hour would reduce the number of cars on the road and encourage improvements to public transport.

Dr Mason says this would encourage walking, cycling and public transport use and reduce pollution and injury from motor vehicles.

“The review is very clear about the use of the tax and transfer system to be used to create the type of society that we want for the future,” she said.

For example, Dr Mason says the review highlights the negative impacts of fringe benefit tax concessions for motor vehicles.

“The taxation system is creating an incentive for individuals to travel additional kilometres to reduce the taxable value of their car,” she said.

Dr Mason says the revenue from scrapping this could be used for better bus services and cycleways.

Breast cancer survivors at increased second cancer risk if they smoke

Washington, May 3 (ANI): A study has found that women who survive early-stage breast cancer have an increased chance of developing a new second cancer in their other breast or elsewhere if they smoke.

Investigators from The Cancer Institute of New Jersey (CINJ) are releasing these findings at an oral presentation during the 92nd Annual Meeting of the American Radium Society taking place this week in Cancun, Mexico.

CINJ is a Center of Excellence of UMDNJ-Robert Wood Johnson Medical School.

It has been shown that women who survive breast cancer have two- to six-times increased risk of developing cancer in their other breast, compared with women who have never had breast cancer.

In hopes of making second cancers less likely, researchers have studied risk factors that can be controlled, such as smoking, obesity and alcohol consumption.

This latest study focused on female smokers with early-stage breast cancer who had breast-conserving therapy to remove their disease.

Breast conserving therapy is the standard treatment given to most patients with early-stage disease and consists of a lumpectomy followed by radiation therapy to the breast.

Data were analysed from 796 self-reported smokers who received breast-conserving therapy between 1975 and 2007 at Yale University School of Medicine.

The team found that at 15 years post-treatment, the risk of developing a new second cancer was significantly greater in smokers compared to non-smokers (25 percent versus 19 percent).

The study also found that smokers had a greater risk of developing cancer in the other breast than those who did not smoke (13 percent versus eight percent) 15 years following treatment.

While correlation was made to other prognostic factors, including age, family history, hormone receptor status and HER2/neu status, smoking was found to be independent of these other indicators.

CINJ Associate Director, Bruce G. Haffty, MD, professor and chair of the Department of Radiation Oncology at UMDNJ-Robert Wood Johnson Medical School, is the senior investigator.

“We believe this study looks at the largest subgroup of women to date on this topic. These new data are significant in that they show women can exercise some control over a known risk factor for developing a new second cancer,” he noted.

The findings are being presented at the annual meeting by Amar Rewari, MD, MBA, who is a resident in Dr. Haffty”s department.

Other collaborators include Sharad Goyal, MD, CINJ and UMDNJ-Robert Wood Johnson Medical School and Meena Moran, MD, Yale University School of Medicine.

Conflicting results on this subject recently appeared in studies published in the Journal of Clinical Oncology and the American Journal of Epidemiology. (ANI)

Regular booze ‘harms those over 60 with health issues, prescription meds’

Washington, Apr 30 (ANI): More than a third of drinkers 60 years old and older consume amounts of alcohol that are excessive or that are potentially harmful in combination with certain diseases they may have or medications they may be taking, a study ahs found.

Basing their research on data from 3,308 older patients accessing primary care clinics around Santa Barbara, Calif., the authors at the David Geffen School of Medicine at UCLA report that just as many individuals were at risk from alcohol consumption in combination with comorbidities or medication as from alcohol consumption alone.

The study, published in the current online edition of the Journal of General Internal Medicine, also found that at-risk drinking was associated with being younger, white and less educated.

“Compared to the U.S. Census population over age 60, the sample studied was more likely to be white, married, well-educated and high-income,” said lead study author Andrew Barnes, a researcher in the UCLA School of Public Health”s department of health services. “However, the adjusted associations of patient demographics with at-risk drinking found in our research should be more generalizable than the descriptive data published previously.”

At-risk drinking was assessed using the Comorbidity Alcohol Risk Evaluation Tool (CARET), which categorizes older adults as at risk if they display at least one of the following drinking behaviors: they consume more than two drinks on most days; they consume one to two drinks on most days and have certain comorbidities, such as gout, hepatitis or nausea; they consume one to two drinks on most days and take select medications, such as antidepressants or sedatives.

“In summary, even among our relatively advantaged study patients, as many as one in three who continued to consume alcohol into older adulthood were at risk of harm from drinking,” the researchers wrote. “Physicians may be less aware of other alcohol-related risk factors common among the elderly (e.g., interactions with select medications and comorbidities) than the risks associated with heavy drinking. Information suggesting which patients have the highest likelihood of at-risk drinking may assist physicians to better target patients for further screening and intervention.” (ANI)

Smoking, boozing, poor diet, lack of exercise can age you by 12 years

Washington, Apr 27 (ANI): Four unhealthy behaviors combined — smoking, lack of physical activity, poor diet and alcohol consumption — can age you by 12 years, claims a new study.

According to a report in the April 26 issue of Archives of Internal Medicine, one of the JAMA/Archives journals, the bad habits appear to be associated with a substantially increased risk of death when combined.

“Several studies have shown that specific health behaviors, including cigarette smoking, physical inactivity, higher alcohol intake and, to a lesser extent, diets low in fruits and vegetables, are associated with an increased risk of cardiovascular disease, cancer and premature mortality [death],” the authors write as background information in the article.

“To fully understand the public health impact of these behaviors, it is necessary to examine both their individual and combined impact on health outcomes,” write Elisabeth Kvaavik, Ph.D., of University of Oslo, Norway, and colleagues.

To reach the conclusion, researchers interviewed 4,886 individuals age 18 or older in 1984 to 1985.

“A health behavior score was calculated, allocating one point for each poor behavior: smoking; fruits and vegetables consumed less than three times daily; less than two hours physical activity per week; and weekly consumption of more than 14 units [one unit equals 8 grams, or about 0.3 ounces] of alcohol (in women) and more than 21 units (in men).”

During an average of 20 years of follow-up, 1,080 participants died—431 from cardiovascular disease, 318 from cancer and 331 from other causes. When compared with participants who had no poor health behaviors, the risk of death from all causes and from each cause increased with each additional behavior.

Individuals with four compared with zero poor health behaviors had about three times the risk of dying of cardiovascular disease or cancer, four times the risk of dying from other causes and an overall death risk equivalent to being 12 years older.

“Modest but achievable adjustments to lifestyle behaviors are likely to have a considerable impact at both the individual and population level,” the authors conclude.

“Developing more efficacious methods by which to promote healthy diets and lifestyles across the population should be an important priority of public health policy.” (ANI)

Study shows breast cancer risk factors differ among races

Washington, April 26 (ANI): A new American research suggests that breast cancer risk factors differ among races.

Breast cancer occurs more frequently in certain ethnic and racial groups, but the reasons behind these differences are not fully understood.

To investigate the issue, Lisa Hines, of the University of Colorado at Colorado Springs led a study that considered how established breast cancer risk factors – including reproductive history, family history of breast cancer, menstrual history, hormone use, alcohol consumption, physical activity, height, and body mass index – might be involved in explaining some of the observed differences in the occurrence of breast cancer among racial and ethnic groups.

They studied breast cancer among women from the Southwest United States who were enrolled in the population-based, case-control 4-Corners Breast Cancer Study, which was designed to investigate factors that contribute to the difference in breast cancer incidence rates observed between Hispanic and non-Hispanic white women.

Prior studies have shown that non-Hispanic white women have a higher incidence of breast cancer than Hispanic women.

In this current study, the researchers found that 62 percent to 75 percent of breast cancer cases among non-Hispanic white women were attributed to known breast cancer risk factors, compared with only 7 to 36 percent of cases among Hispanic women.

Hispanic women were more likely to have characteristics associated with lower breast cancer risk, such as earlier age at first childbirth, having more children, shorter height, less hormone use, and less alcohol consumption.

Among premenopausal women, taller height and family history of breast cancer were associated with increased risk in non-Hispanic white women but were not among Hispanic women.

Among postmenopausal women, certain breast cancer risk factors in non-Hispanic whites (such as recent hormone therapy use and younger age at menarche) had no or only weak associations with breast cancer in Hispanics.

These findings suggest that many of the risk factors studied to date explain fewer of the breast cancer cases that arise in Hispanic women compared with non-Hispanic white women.

Dr. Hines said: “These differences are likely to contribute to disparities in breast cancer incidence rates, and could potentially reflect differences in breast cancer development among these ethnic groups.”

For instance, ethnic differences in genetic and environmental or lifestyle factors may affect individuals” susceptibility to the development of breast cancer.

The authors noted that the study”s findings also indicate that the use of models to estimate a woman”s risk of breast cancer that were developed from studies among non-Hispanic white populations need to be evaluated among other ethnic and racial populations.

The study has appeared early online in Cancer, a peer-reviewed journal of the American Cancer Society. (ANI)

1 in 10 Brits consumes 20 pints in an evening

Washington, April 20 (ANI): A study has found that extreme alcohol consumption in Britain is very much prevalent, with one in ten revellers drinking more than 40 units of alcohol in an evening.

The study conducted in the North West of England used measures of blood alcohol concentration, self-assessed and observer-assessed drunkenness to confirm that binge drinking is prevalent.

Researchers interviewed and ”breathalysed” revellers, finding that one in ten intended to drink more than 40 units by home time, with those using extended licensing hours having the most extreme alcoholic intentions.

Mark Bellis, from Liverpool John Moores University, worked with a team of researchers to carry out the study on 214 people in the city centres of Chester, Liverpool and Manchester.

“The UK has a well established culture of heavy drinking in nightlife settings. Despite this, there is relatively little information available on drunkenness with laws restricting sales of alcohol to drunk individuals being largely ignored,” he said.

“Using new techniques we examined the amounts people had drunk at interview and planned to continue to drink before going home.

“Combined with blood alcohol concentration measurement this provides a method for examining even extreme levels of alcohol consumption without exposing researchers to highly inebriated consumers who cannot remember how much they have drunk,” he stated.

Just over half (51 percent) of the people who reported feeling drunk at the interview said they intended to drink more alcohol that night.

The researchers also found that when individuals were informed about their blood alcohol level, it was more likely to encourage them to drink (nearly 1 in 4) than to reduce their alcohol consumption that night (less than 1 in 25).

“Commercial use of breathalysers to encourage individuals to drink more has already been attempted in some bars in the UK. As such technologies become more easily accessible there is a real danger it will further increase alcohol consumption,” Bellis said.

“Cities in the UK have adopted costly nightlife policing strategies aimed at protecting patrons from immediate alcohol-related harms by controlling violence and other anti-social behaviour.

“Implementing safety measures in nightlife environments is crucial to protecting public health, yet without reasonable efforts to reduce nightlife alcohol consumption, such measures may simply result in safer environments for drunks,” Bellis added about the results.

The findings have been published in BioMed Central”s open access journal Substance Abuse Treatment, Prevention and Policy. (ANI)

Gate City Beverage Distributors and Heineken USA Provide Tips to Rock Out Responsibly at the Coachella Music and Arts

COACHELLA VALLEY, CA, Apr 14 (MARKET WIRE) —
Gate City Beverage Distributors and Heineken USA today announced a joint
effort to help concert-goers safely enjoy three days of music and
festivities at the 11th Annual Coachella Valley Music and Arts Festival
in Indio, Calif. Through a targeted PSA program, the companies will
provide pointers to help music fans make the most of their Coachella
experience by acting and consuming responsibly.

Displayed on-site at the Coachella grounds as well as at surrounding
hotels and licensed establishments in the Coachella Valley, this series
of posters will remind attendees to wear sunscreen, layer clothing
appropriately, drink plenty of water, recycle, and if drinking alcohol,
to manage their alcohol consumption responsibly.

“The incredible setting and high-caliber artists make Coachella a premier
music festival. We are proud that our efforts in partnership with
Heineken USA will help ensure that concert goers don’t miss a beat of
this fantastic weekend,” said Thomas Reyes, president, Gate City Beverage
Distributors.

This year’s efforts mark Gate City Beverage Distributors and Heineken
USA’s ninth annual involvement with the Coachella Valley Music and Arts
Festival and underscore the organizations’ ongoing commitment to
promoting responsible behavior throughout Southern California.

“Being an active and responsible member of the communities where our
products are enjoyed is one of the foundational values of our
organization,” said Allan O’Neil, regional vice president, Heineken USA.
“The Coachella Valley Music and Arts Festival is the perfect setting to
demonstrate our commitment to these values as we help our consumers give
themselves a good name by exhibiting safe and responsible behavior while
enjoying time with friends and top-quality music at one of the most
impressive events of the year.”

About Gate City Beverage Distributors
Gate City Beverage Distributors
provide a wide selection of high quality beverage products to retailers
throughout Southern California’s Inland Empire. Gate City Beverage
Distributors is a Reyes Holdings company and part of Reyes Beverage
Group, the largest beer distribution business in the United States. For
more information about Gate City Beverage Distributors, visit the company
website at www.gatecitybeverage.com.

About Heineken USA
Heineken USA Inc., the nation’s premier beer
importer, is a subsidiary of Heineken International BV, which is the
world’s most international brewer. Brands imported into the U.S. include:
Heineken Lager, the world’s most international beer brand; Heineken
Light; Amstel Light, a leading imported light beer brand; Newcastle Brown
Ale, the leading imported ale in the United States; and Buckler
non-alcoholic brew. Heineken USA is also the exclusive USA importer for
the Tecate, Tecate Light, Dos Equis, Sol, Carta Blanca and Bohemia brands
from FEMSA Cerveza of Mexico. For a safe ride home, download the Heineken
USA-sponsored Taxi Magic(TM) application from your smartphone. Please
visit www.EnjoyHeinekenResponsibly.com.

Copyright 2010, Market Wire, All rights reserved.

Man dies after crashing through nightclub window

A man is dead and two others injured after they fell through a nightclub window on the Gold Coast.

Police and building inspectors are investigating the fatal fall.

Police say three men crashed through a full-length glass window and fell nine metres to the ground outside the SAR Club in Orchid Avenue just before 1am AEST.

Paramedics treated them but the 19-year-old man died at the scene.

Two 18-year-old men are in hospital in a serious but stable condition.

Police say Workplace Health and Safety officers and building inspectors will compile reports and they will be sent to the coroner.

A post mortem examination is also expected to be done today.

Police on the Gold Coast say it is unlikely charges will be laid over the fatal fall.

Superintendent Jim Keogh says he has viewed security footage of the incident and a report is being prepared for the coroner.

“They’ve overbalanced – the full-length glass has given way, broken and the three have fallen the nine metres to the pavement below,” he said.

“It was a minor grapple – there was no punches thrown.”

Superintendent Keogh says the cause of the incident is not clear.

“That’s still the subject of an investigation at the moment being conducted by Surfers Paradise CIB,” he said.

Superintendent Keogh says it is to early to know whether the incident was alcohol fuelled.

“It is something that obviously the investigators will look at the alcohol consumption of all involved,” he said.

Uric acid levels, obesity, alcohol use among factors linked to women””s gout risk

Washington, Mar 31 (ANI): Women with serum uric acid levels over 5 mg/dl have a significantly lower risk of developing gout than men, Boston University School of Medicine have discovered.

The study, the first to examine the relationship between uric acid levels and gout risk in women, also evaluated purported risk factors for gout and found that increasing age, obesity, hypertension, alcohol use, and diuretic use to be among leading contributors for women.

Results of the 52-year follow-up study are published in the April issue of Arthritis & Rheumatism, a journal of the American College of Rheumatology.

Gout is a common and excruciatingly painful inflammatory arthritis caused by elevated uric acid levels in the blood.

When too much uric acid builds up in joint fluid, uric acid crystals form and cause joint swelling and inflammation. Historically, gout was seen as a male disease, however growing evidence suggests the disease is also a concern for older women.

In the latest study, the research team led by Hyon Choi, M.D., D.Ph., analyzed data from the Framingham Heart Study for 2,476 women and 1,951 men who had a complete follow-up history and who were free of gout at baseline. The mean age at baseline was 47 years for women and 46 years for men.

Researchers evaluated serum uric acid levels and risk factors for gout that included: age, body mass index (BMI), alcohol consumption, hypertension, medication use (diuretics, hormone replacement therapy), blood glucose and cholesterol levels, and menopause status. At baseline the mean serum uric acid level was 4.0 mg/dl for women and 5.1 mg/dl for men.

“We identified 104 gout cases in women and 200 in men over the 28-year median follow-up period,” said Dr. Choi. “The gout incidence per 1,000 person-years was 1.4 in women and 4.0 in men.”

Results also found among the purported risk factors for gout, increasing age, obesity, alcohol consumption, diuretic use, and hypertension were independently associated with higher risk of gout incidence in women. However, researchers found only a stronger age effect among women placed them at higher risk factors for gout than men. The age-adjusted relative risk (RR) of gout in post-menopausal women was 4.18 and the RR for gout in women using hormone replacement therapy was 0.24. Other risk factors did not differ significantly between women and men.

“Our study found that higher levels of uric acid in the blood increase the risk gout risk for women in a graded manner,” concluded Dr. Choi. (ANI)

Floor price for booze as good as taxes: study

Raising the minimum price for alcohol is as effective as raising taxes at reducing the harm caused by alcohol consumption, according to a study in the UK.

Scotland is considering bringing in a minimum price for alcohol with a series of other measures which the government says will reduce alcohol consumption and save lives.

According to findings of the study by the University of Sheffield’s Robin Purshouse and his colleagues, that may just be right.

Dr Purshouse and his team explored the impact of 18 different pricing policies on changes in alcohol consumption and the associated healthcare costs.

The research, published in medical journal The Lancet, found that alcohol consumption decreased as prices rose.

“General price increases were effective for reduction of consumption, healthcare costs, and health-related quality of life losses in all population subgroups,” the report said.

“Minimum pricing policies can maintain this level of effectiveness for harmful drinkers while reducing effects on consumer spending for moderate drinkers.”

Alcohol consumption is estimated to cost Australia $10.83 billion in lost productivity, health care, road accidents and crime.

‘No argument’

Australian experts say the findings of the study are relevant to Australia.

Wayne Hall of the University of Queensland’s Centre for Clinical Research says there is “no argument” that increasing the price of alcohol reduces consumption.

“That’s the finding of every study that’s ever been done on modelling the effect of raising prices,” he said.

Dr Hall says the new study supports the findings of similar Australian research.

But while most studies have looked at the effect of a “volumetric tax”, which increases with the alcohol content of beverages, another approach is to raise the minimum price.

Dr Hall says the study by Dr Purshouse shows raising the minimum price for alcohol has the roughly equivalent effect of raising taxes.

He says the argument in favour of setting a “floor price” is that it targets those who drink the most.

“The heavier drinkers are typically young adults and they tend to prefer the cheapest beverages available,” he said, adding that some cask wine is cheaper than bottled water.

“So if you were to raise the minimum price and make the cheaper beverages more expensive, you’d have a bigger impact on their consumption than you might if you raised taxes across the board.”

Anti-competitive?

Gino Vambuca of the Australian National Council on Drugs (ANCD), the main advisory body to the Government on drug policy, agrees pricing and taxation is the most effective way to reduce alcohol consumption.

But he says producers who want alcohol treated as any other commodity may regard setting a floor price as an anti-competitive policy.

Australia is awaiting the Government’s response to a review of taxation and a report on preventative health.

“That’s where the opportunity is for us,” Mr Vambuca said.

The ANCD is calling for a volumetric tax, disincentives for products that can have a high potential for harm and incentives for low-alcohol products.

“There should be a bigger price disparity between low-alcohol beer and full-strength beer,” Mr Vambuca said.

He says taxes should be spent on domestic violence shelters, drug and alcohol treatment centres and road trauma wards.

Blood proteins may offer alcohol abuse test

Washington, March 24 (ANI): Penn State College of Medicine researchers say that measuring a set of protein changes in the blood linked to alcohol use may potentially lead to a more accurate diagnostic test than those currently available.

“The challenge in alcohol abuse as opposed to substance abuse — things like cocaine or heroin or PCP — is that alcohol is a perfectly legal substance for those over 21,” said Willard M. Freeman, department of pharmacology and lead investigator.

“Unlike routine testing for illicit drugs, you can”t just look for a trace of alcohol because many people enjoy a drink in a responsible manner and alcohol is very quickly metabolized. Discriminating between excessive and responsible levels of drinking makes this a greater challenge,” Freeman added.

The researchers identified a set of 17 proteins in the blood that accurately predicted alcohol usage 90 percent of the time in non-human primates.

Researchers were able to separate usage into three categories — no alcohol use, drinking up to two drinks per day and drinking at least six drinks per day.

Protein levels rose and declined depending on alcohol consumption.

“We observed that the levels of some proteins increased or decreased with as little as one or two drinks a day. These same changes occurred with heavier levels of drinking. We also found other proteins that responded only to heavy levels of drinking. Combined, these proteins allow us to classify subjects into non-drinking, alcohol-using, and alcohol-abusing groups,” Freeman said.

The study was published online in the journal Biological Psychiatry. (ANI)

Crook Cousins ‘not warned about booze’

Richmond has denied media reports that Ben Cousins has been warned about excessive drinking, after the star midfielder was admitted to hospital twice in the last week with stomach pains.

After being readmitted to hospital yesterday with a stomach ailment, Cousins was discharged from hospital on Tuesday morning and is expected to train with the side this week.

The club says Cousins underwent more tests this morning, but the results may not be known for several days.

Reacting to claims today that Cousins had been warned by the Tigers to stop binge drinking, Richmond said he had never been spoken to “individually” about alcohol consumption.

He was first admitted to hospital five days ago to be treated for a stomach complaint before being released.

But he was re-admitted at the weekend after suffering pain, according to one report.

The club rejected the claim he had been warned by club officials that binge drinking might shorten his career.

“In response to media speculation raised today, the Richmond Football Club confirms that Ben Cousins has never been spoken to individually with regards to binge drinking,” the statement said.

“The Club is extremely proactive in educating players around what is considered responsible and appropriate behaviour, and all players, as part of their development, are involved in regular education sessions.”

However the club did not respond to the suggestion that Cousins was now certain to miss the Tigers’ season-opening match against Carlton on March 25.

- ABC/AAP

Chronic alcohol disrupts body’s biological clock

Washington, Sept 1 (ANI): Chronic alcohol consumption can adversely affect body’s biological clock’s ability to synchronize daily activities to light, according to a new study on hamsters.

It continues to affect the body’s clock (circadian rhythm), even days after the drinking ends.

The researchers from Kent State University and the University of Tennessee have shown that alcohol consumption affects the master clock, located in the suprachiasmatic nucleus (SCN) section of the brain.

This clock controls the circadian cycle, a roughly 24-hour cycle, which regulates sleeping and waking, as well as the timing of a variety of other physiological functions, such as hormonal secretions, appetite, digestion, activity levels and body temperature.

Disruption of the clock dramatically increases the risks of developing cancer, heart disease, and depression, among other health problems.

In the new study, the researchers used hamsters to find out how alcohol affects circadian rhythms. The control group received water only. A second group received water containing 10pct alcohol and the third group received water containing 20pct alcohol.

The hamsters that drank alcohol had the hardest time shifting their rhythms after exposure to the dim light.

The more alcohol they drank, the harder it was to adjust.

Exposure to dim light caused the water-only hamsters to wake up 72 minutes earlier than they normally would. The 10pct alcohol group woke up 30 minutes earlier and the 20pct alcohol group woke up only 18 minutes earlier.

The hamsters that consumed alcohol had fewer bouts of activity that lasted longer than the water-consuming controls.

Chronic drinking continues to affect the biological clock even after withdrawal from alcohol.

The researchers aim to apply the research to people, who also show circadian disruptions from drinking.

It suggests that people who drink alcohol, particularly late into the night, may not respond to important light cues to keep their biological clocks in synch with daylight over the next 24 hours. Even low levels of alcohol may impair the response to light cues.

After the first 24 hours, the circadian cycle continues to be affected, even without further consumption of alcohol.

The findings appear in the American Journal of Physiology – Regulatory, Integrative and Comparative Physiology. (ANI)

Teetotallers ‘at increased depression risk’

Washington, Aug 29 (ANI): A new study has found that people abstaining from alcohol are at greater risk of suffering from depression as compared to those who consume it.

Nord-Trøndelag Health Study (HUNT study), which was based in Norway, was based on 38,000 individuals.

The report showed that those individuals who avoided alcohol over a two-week period were more likely than moderate drinkers to get symptoms of depression.

Especially, individuals who additionally labeled themselves as “abstainers” were at the highest risk of depression.

Some other factors, which could be the reason for feeling low, are age, physical health problems but it still does not explain all the increased risk.

The authors also had access to reported levels of alcohol consumption 11 years prior to the main survey.

It helped show that fourteen percent of current abstainers had previously been heavy drinkers, but this did not explain all of the increased risk of depression amongst abstainers.

However, the current guidance is for men to drink no more than three to four units each day, and women to drink no more than two to three units. (ANI)

Brits drinking more ‘by stealth’ – thanks to stronger booze

London, August 27 (ANI): People are taking in more booze “by stealth”, thanks to stronger drinks that are on sale, according to an analysis of consumption in the UK.

Researchers Mintel, who headed the survey, found the alcohol consumption level per person had leaped by 10 per cent since last nine years despite steady drink sales.

The research firm suggested the change could be linked to wines and lagers that were boasting of stronger alcohol content than before, leaving people unaware of the changes, reports the BBC.

Mintel, that also used data from a series of sources such as the NHS and sales information from shops, bars and pubs, said the alcohol content of wine is now normally around 13 per cent as compared to an estimated 11 per cent in the past.

Premium 5 per cent lagers were also growing in popularity.

Jonny Forsyth, a senior drinks analyst at Mintel, said: “It may be that the majority of consumers are not aware of ABV (alcohol by volume).

“So despite a greater societal concern with being healthy leading to a decline in drinking penetration, by stealth we are drinking more pure alcohol than ever.”

Don Shenker, chief executive of Alcohol Concern, added: “Consumers have limited information to help them make healthy choices about their alcohol consumption.

“There is often no information about units and even rarer information about sensible drinking levels on the labels of alcohol products.

“The increasing strength of wines and beers means we are often drinking at harmful levels without realising it.” (ANI)

Heavy drinking ‘cuts dementia risk’

Washington, Aug 27 (ANI): People who drink up to 28 drinks a week in later life are less likely to develop dementia than people who abstain from alcohol consumption, according to a new study.

Professor Kaarin Anstey, from Canberra’s Australian National University, and colleagues compiled data from 15 international studies, including responses from more than 10,000 people.

They found that drinkers are better off when it comes to developing diseases affecting cognitive function, reports the Daily Telegraph.

The researchers found that those aged 60 and older who consumed between one and 28 alcoholic drinks each week, were almost 30 per cent less likely to have Alzheimer’s later on in life.

Light and moderate drinkers were also 25 per cent less likely to contract vascular dementia, and 26 per cent less likely to suffer from any form of dementia, the authors found.

The odds improved even more when comparing just drinkers with non-drinkers and ignoring exactly how much people consumed.

However, Anstey warned that this was not encouragement for people to start swilling 28 glasses of alcohol a week.

Even though, the study found imbibers, in general, had a 47 per cent reduced risk of contracting dementia compared with teetotalers, down to 44 per cent for Alzheimer’s.

Anstey said that there was a clear link between drinking and a reduced risk of dementia.

The researchers also found that the relationship between drinking and dementia was the same for men and women.

Although it was unclear exactly why light drinking provoked such a benefit, Anstey suggested that it might have something to do with alcohol’s ‘protective effect’ on reducing inflammation and heart disease.

The report was published in the July edition of the American Journal of Geriatric Psychiatry. (ANI)